Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383593 | 0.84 | GSK3B (0.72) | GSK3BSMN1; SMN2GPR84HCAR2KMT2A | |
| SCHEMBL5382157 | 0.83 | GSK3B (0.68) | GSK3BSMN1; SMN2GPR84HCAR2ALDH1A1 | |
| SCHEMBL5375436 | 0.82 | GSK3B (0.48) | GSK3BGPR84HCAR2 | |
| SCHEMBL5387930 | 0.82 | GSK3B (1.00) | GSK3BSMN1; SMN2GPR84KMT2A | |
| SCHEMBL5386069 | 0.77 | GSK3B (0.69) | GSK3BSMN1; SMN2GPR84HCAR2BACE1 | |
| SCHEMBL5390685 | 0.74 | GSK3B (1.00) | GSK3BSMN1; SMN2KMT2ABACE1 | |
| SCHEMBL25403779 | 0.73 | NOS3 (0.44) | SMN1; SMN2HPGD | |
| SCHEMBL5659777 | 0.71 | SMN1; SMN2 (1.00) | GSK3BSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL5386254 | 0.71 | GSK3B (1.00) | GSK3BSMN1; SMN2GPR84 | |
| SCHEMBL5390578 | 0.70 | GSK3B (0.67) | GSK3BSMN1; SMN2GPR84HCAR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |