SCHEMBL538610

SCHEMBL538610

Cc1ccc(-c2c(N)ccc(-c3ccccc3)c2-c2ccc(C)c(C)c2)cc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.43
MEN1 O00255 1/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
KMT2A Q03164 1/20 0.43
PTGS2 P35354 5/20 0.43
PTGS1 P23219 3/20 0.43
CYP3A4 P08684 1/20 0.42
TSHR P16473 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ESR2 Q92731 1/20 0.40
HSD17B10 Q99714 1/20 0.38
PDE4A P27815 1/20 0.38
PDE4B Q07343 1/20 0.38
PDE4C Q08493 1/20 0.38
PDE4D Q08499 1/20 0.38
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38
DHFR P00374 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7728892 0.83 ALDH1A1 (0.43) ALDH1A1MEN1LMNAMAPTMAPK1
SCHEMBL21164633 0.81 ALDH1A1 (0.52) ALDH1A1MEN1LMNAMAPTMAPK1
SCHEMBL28243656 0.81 ALDH1A1 (0.42) ALDH1A1MEN1LMNAMAPTKMT2A
Ammonia Solution, Strong SCHEMBL1411404 0.80 RAB9A (0.45) ALDH1A1MEN1KMT2ATSHRHSD17B10
SCHEMBL845162 0.80 HSD17B10 (0.52) ALDH1A1LMNAMAPTMAPK1CYP3A4
SCHEMBL30866155 0.80 HSD17B10 (0.52) ALDH1A1LMNAMAPTMAPK1CYP3A4
SCHEMBL27948347 0.79 ADORA1 (0.41) ALDH1A1MEN1MAPTKMT2AESR2
Ammonia Solution, Strong SCHEMBL28028584 0.78 HSD17B10 (0.50) ALDH1A1LMNAMAPTMAPK1CYP3A4
Ammonia Solution, Strong SCHEMBL5878673 0.77 MEN1 (0.43) ALDH1A1MEN1LMNAMAPTMAPK1
SCHEMBL651427 0.77 HSD17B10 (0.54) ALDH1A1MEN1LMNAMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10212267-A None JP disclosed
JP-10212268-A None JP disclosed
US-8173343-B2 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH COMPANY, LTD. (JP) 2012-05-08 US disclosed
EP-2146251-B1 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH CO LTD (JP) 2012-02-08 EP disclosed
US-20100015538-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS USING THE SAME, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2010-01-21 US disclosed
EP-2146251-A1 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge Ricoh Company, Ltd. (JP) 2010-01-20 EP disclosed
US-5902901-A Arylamine processes XEROX CORPORATION (US) 1999-05-11 US disclosed
JP-H10212267-A PROCESS FOR PREPARING ARYLAMINE XEROX CORP 1998-08-11 JP disclosed
JP-H10212268-A PROCESS FOR PREPARING ARYLAMINE XEROX CORP 1998-08-11 JP disclosed
EP-0856508-A1 Processes for the preparation of arylamines XEROX CORPORATION (US) 1998-08-05 EP disclosed
US-5723669-A Arylamine processes XEROX CORPORATION (US) 1998-03-03 US disclosed
US-5723671-A Arylamine processes XEROX CORPORATION (US) 1998-03-03 US disclosed
US-5705697-A ULLMAN CONDENSATION OF IODOXYLENE WITH N-(3,4-DIMETHYLPHENYL)-4-BIPHENYLAMINE CATALYZED BY COPPER/I/ COMPLEXED TO NITROGEN-CONTAINING HETEROARYL LIGAND XEROX CORPORATION (US) 1998-01-06 US disclosed