Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | REN | P00797 | 4/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386298 | 1.00 | KLK5 (0.57) | KLK5ATMKMT2AMEN1REN | |
| SCHEMBL5220702 | 0.95 | REN (0.58) | KLK5ATMREN | |
| SCHEMBL30318981 | 0.95 | REN (0.58) | KLK5ATMREN | |
| SCHEMBL5400906 | 0.93 | KLK5 (0.52) | KLK5ATMKMT2AMEN1REN | |
| SCHEMBL5400909 | 0.93 | KLK5 (0.52) | KLK5ATMKMT2AMEN1REN | |
| SCHEMBL7309908 | 0.90 | KLK5 (0.65) | KLK5ATMBCHEBACE1 | |
| SCHEMBL13618023 | 0.88 | YAP1 (0.51) | KLK5REN | |
| SCHEMBL5223284 | 0.86 | KLK5 (0.61) | KLK5ATMBCHEBACE1 | |
| SCHEMBL4809494 | 0.86 | ATM (0.72) | KLK5ATMBCHEBACE1 | |
| SCHEMBL495728 | 0.86 | ATM (0.72) | KLK5ATMBCHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153561-B1 | 9H-FLUOREN DERIVATES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | UNIV JAGIELLONSKI (PL) | 2026-04-29 | — | — | EP | disclosed |
| US-12492163-B2 | 9H-fluorene derivatives or their pharmaceutically acceptable salts | UNIWERSYTET JAGIELLONSKI (PL) | 2025-12-09 | — | — | US | disclosed |
| US-20230117233-A1 | NOVEL 9H-FLUORENE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | UNIWERSYTET JAGIELLONSKI (PL) | 2023-04-20 | — | — | US | disclosed |
| EP-4153561-A2 | 9H-FLUOREN DERIVATES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | UNIWERSYTET JAGIELLONSKI (PL) | 2023-03-29 | — | — | EP | disclosed |
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230117233-A1 | NOVEL 9H-FLUORENE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | BACE1, BACE2, APP | KLK5 3076/4885ATM 3819/4885KMT2A 3228/4885 |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | KLK5 3361/4885ATM 870/4885KMT2A 300/4885 |
| US-12492163-B2 | 9H-fluorene derivatives or their pharmaceutically acceptable salts | BACE1, BACE2, APP | KLK5 3203/4885ATM 3722/4885KMT2A 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.