Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.82 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778634 | 0.85 | SIGMAR1 (0.62) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL8197807 | 0.85 | SIGMAR1 (0.62) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL15236204 | 0.85 | ALDH1A1 (0.77) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL2978379 | 0.82 | MC4R (0.70) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL4214758 | 0.82 | SIGMAR1 (0.62) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL3769864 | 0.82 | SIGMAR1 (0.63) | SIGMAR1TSHRCYP2D6HTR2AHTR2C | |
| SCHEMBL2524084 | 0.81 | ALDH1A1 (0.62) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL18203105 | 0.81 | SIGMAR1 (0.61) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL4020289 | 0.80 | ALDH1A1 (0.60) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL2086761 | 0.80 | TSHR (0.70) | SIGMAR1TSHRCYP2C19ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414366-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | Novartis AG (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-20120010135-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2012-01-12 | — | — | US | disclosed |
| WO-2010112520-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | NOVARTIS AG (CH) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010135-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | SCD, SCD5, FADS2 | SIGMAR1 2897/4885TSHR 2881/4885CYP2C19 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.