SCHEMBL5388447

SCHEMBL5388447

C[Si](C)(Cc1ccccc1)O[Si](C)(C)Cc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
ALDH1A1 P00352 1/20 0.42
TP53 P04637 1/20 0.42
AOC3 Q16853 2/20 0.39
TAAR1 Q96RJ0 2/20 0.39
CALM1 P0DP23 1/20 0.39
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
IDO1 P14902 2/20 0.37
HPGD P15428 1/20 0.37
LTA4H P09960 1/20 0.37
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
ADRA2A P08913 1/20 0.36
CYP2D6 P10635 1/20 0.36
ADRA2B P18089 1/20 0.36
ADRA2C P18825 1/20 0.36
ADRA1D P25100 1/20 0.36
ADRA1A P35348 1/20 0.36
ADRA1B P35368 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8320761 0.91 TP53 (0.41) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL13550868 0.91 TSHR (0.39) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL14665751 0.91 TSHR (0.39) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL16543227 0.85 TSHR (0.35) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL7140508 0.85 TSHR (0.35) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL14665752 0.83 TSHR (0.37) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL14665839 0.83 TSHR (0.37) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL15893214 0.83 TSHR (0.37) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL109029 0.83 TSHR (0.41) TSHRALDH1A1TP53AOC3TAAR1
SCHEMBL243501 0.81 TSHR (0.39) TSHRALDH1A1TP53AOC3TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116176082-A POE material-based composite high-barrier film and application thereof 浙江中聚材料有限公司 2023-05-30 CN claimed
CN-115793392-A White solder resist dry film with good yellowing resistance and preparation method thereof 广东硕成科技股份有限公司 2023-03-14 CN claimed
CN-115561965-A Solder resist dry film capable of resisting chemical reagent and preparation method thereof 广东硕成科技股份有限公司 2023-01-03 CN claimed
EP-0396122-A2 Ambient temperature curable polyorganosiloxanes UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC. (US) 1990-11-07 EP claimed
US-4242479-A CATALYST OF ALUMINUM TRIHALIDE, ORGANOSILOXANE COMPOUND OR ETHER, MAGNESIUM ALCOHOLATE, TITANIUM-HALOGEN AND ORGANOALUMINUM COMPOUNDS SHOWA YUKA KABUSHIKI KAISHA (JP) 1980-12-30 US claimed
CN-115561965-B Chemical reagent resistant dry film solder resist and preparation method thereof 广东硕成科技股份有限公司 2025-05-27 CN disclosed
CN-116176082-B POE material-based composite high-barrier film and application thereof 浙江中聚材料有限公司 2025-04-04 CN disclosed
US-20230340177-A1 COMPOSITION AND SILOXANE-BASED THERMOPLASTIC RESIN USING SAME, AND METHODS FOR PRODUCING SAME MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2023-10-26 US disclosed
CN-116176082-A POE material-based composite high-barrier film and application thereof 浙江中聚材料有限公司 2023-05-30 CN disclosed
CN-115793392-A White solder resist dry film with good yellowing resistance and preparation method thereof 广东硕成科技股份有限公司 2023-03-14 CN disclosed
CN-115561965-A Solder resist dry film capable of resisting chemical reagent and preparation method thereof 广东硕成科技股份有限公司 2023-01-03 CN disclosed
CN-109824710-A A kind of disiloxane class organic compound and preparation method 云南民族大学 2019-05-31 CN disclosed
US-7105467-B2 Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives PHARMACORE, INC. (US) 2006-09-12 US disclosed
US-20050256317-A1 Process for selective production of aryl 5-thio-beta-d- aldohexopyranosides TAISHO PHARMACEUTICAL CO., LTD. (JP) 2005-11-17 US disclosed
EP-1541578-A1 PROCESS FOR SELECTIVE PRODUCTION OF ARYL 5-THIO-BETA-D-ALDOHEXOPYRANOSIDES TAISHO PHARMACEUTICAL CO., LTD (JP) 2005-06-15 EP disclosed
US-20050010073-A1 Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives DSM IP ASSETS B.V. (NL) 2005-01-13 US disclosed
EP-0490480-A1 Preparation of aluminum oxynitride from organosiloxydihaloalanes FORD MOTOR COMPANY LIMITED (GB) 1992-06-17 EP disclosed
US-5075265-A Preparation of aluminum oxynitride from organosiloxydihaloalanes FORD MOTOR COMPANY (US) 1991-12-24 US disclosed
US-4242479-A CATALYST OF ALUMINUM TRIHALIDE, ORGANOSILOXANE COMPOUND OR ETHER, MAGNESIUM ALCOHOLATE, TITANIUM-HALOGEN AND ORGANOALUMINUM COMPOUNDS SHOWA YUKA KABUSHIKI KAISHA (JP) 1980-12-30 US disclosed
US-4180636-A MAGNESIUM HALIDE, TITANIUM COMPOUND ELECTRON DONOR COMPOUND, TRIALKYL ALUMINUM CATALYST SHOWA DENKO KABUSHIKI KAISHA (JP) 1979-12-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050010073-A1 Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives NISCH, NPM1, AP1M1 TSHR 4740/4885ALDH1A1 3581/4885TP53 3948/4885
US-20050256317-A1 Process for selective production of aryl 5-thio-beta-d- aldohexopyranosides ALDOA, DERA, AKR1D1 TSHR 206/4885ALDH1A1 65/4885TP53 2693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.