Hydrochloric Acid

Hydrochloric Acid

SCHEMBL538955

CC(C)(C)c1ccc2c(c1)C([Zr+2]1(C3c4cc(C(C)(C)C)ccc4-c4ccc(C(C)(C)C)cc43)CC1)c1cc(C(C)(C)C)ccc1-2.[Cl-].[Cl-]

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.37
NPC1 O15118 1/20 0.37
PLA2G1B P04054 1/20 0.37
NFKB1 P19838 1/20 0.37
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
ATG4B Q9Y4P1 1/20 0.37
HPGD P15428 2/20 0.34
ALOX15 P16050 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CYP19A1 P11511 1/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2C19 P33261 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7196668 0.83 ALDH1A1 (0.33) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL7199314 0.77 ALDH1A1 (0.32) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL2863150 0.75
Hydrochloric Acid SCHEMBL31356224 0.73 ALDH1A1 (0.41) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL540565 0.73 ALDH1A1 (0.41) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL8853890 0.73 ALDH1A1 (0.41) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL5086021 0.73 ALDH1A1 (0.41) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL541054 0.73 ALDH1A1 (0.41) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL540419 0.73 ALDH1A1 (0.41) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrochloric Acid SCHEMBL2854861 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2460834-B1 Improved acidic activator-supports and catalysts for olefin polymerization CHEVRON PHILLIPS CHEMICAL CO (US) 2015-08-12 EP disclosed
EP-2460834-A1 Improved acidic activator-supports and catalysts for olefin polymerization Chevron Phillips Chemical Company LP (US) 2012-06-06 EP disclosed
EP-1773897-B1 IMPROVED ACIDIC ACTIVATOR-SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION CHEVRON PHILLIPS CHEMICAL CO (US) 2012-02-08 EP disclosed
US-7790820-B2 Acidic activator-supports and catalysts for olefin polymerization CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2010-09-07 US disclosed
US-20100029872-A1 ACIDIC ACTIVATOR-SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2010-02-04 US disclosed
US-7629284-B2 Acidic activator supports and catalysts for olefin polymerization CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2009-12-08 US disclosed
US-20080026934-A1 ACIDIC ACTIVATOR SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION CHEVRON PHILLIPS CHEMICAL COMPANY (US) 2008-01-31 US disclosed
US-7294599-B2 Acidic activator-supports and catalysts for olefin polymerization CHEVRON PHILLIPS CHEMICAL CO. (US) 2007-11-13 US disclosed
EP-1773897-A2 IMPROVED ACIDIC ACTIVATOR-SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION Chevron Phillips Chemical Company LP (US) 2007-04-18 EP disclosed
WO-2006012321-A2 IMPROVED ACIDIC ACTIVATOR-SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2006-02-02 WO disclosed
US-20050288178-A1 Acidic activator-supports and catalysts for olefin polymerization CHEVRON PHILLIPS CHEMICAL COMPANY 2005-12-29 US disclosed