Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846300 | 0.89 | NPC1 (0.55) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19665231 | 0.82 | HPGD (0.53) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5396521 | 0.79 | KDM4E (0.50) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5381545 | 0.78 | CDC7 (0.59) | NPY5RALDH1A1KDM4EHPGDHPGDS | |
| SCHEMBL31074765 | 0.78 | SCN2A (0.49) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5390774 | 0.77 | GSK3B (0.66) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5384453 | 0.76 | CYP19A1 (0.59) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10838008 | 0.75 | KDM4E (0.50) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL28681344 | 0.74 | SMN1; SMN2 (0.53) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9846148 | 0.73 | BTK (0.46) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |