Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424846 | 0.83 | EPHX2 (0.56) | EPHX2LIPEKMT2AMEN1EPHX1 | |
| SCHEMBL424845 | 0.83 | EPHX2 (0.56) | EPHX2LIPEKMT2AMEN1EPHX1 | |
| SCHEMBL538758 | 0.79 | EPHX2 (0.46) | EPHX2LIPEEPHX1MMP9MMP1 | |
| SCHEMBL539061 | 0.79 | EPHX2 (0.46) | EPHX2LIPEKMT2AMEN1EPHX1 | |
| SCHEMBL2171738 | 0.76 | EPHX2 (0.43) | EPHX2LIPEKMT2AMEN1EPHX1 | |
| SCHEMBL3717658 | 0.71 | ALDH1A1 (0.56) | EPHX2LIPEKMT2AMEN1MMP9 | |
| SCHEMBL421549 | 0.70 | EPHX2 (0.62) | EPHX2LIPEKMT2AMEN1EPHX1 | |
| SCHEMBL421550 | 0.70 | EPHX2 (0.62) | EPHX2LIPEKMT2AMEN1EPHX1 | |
| SCHEMBL2171525 | 0.69 | MEN1 (0.45) | EPHX2LIPEKMT2AMEN1EPHX1 | |
| SCHEMBL421636 | 0.68 | EPHX2 (0.57) | EPHX2LIPEKMT2AMEN1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414332-A1 | ACRYLAMIDE COMPOUNDS AND THE USE THEREOF | Shionogi & Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114181-A1 | ACRYLAMIDE COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2010-10-07 | — | — | WO | disclosed |