Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 4/20 | 0.35 |
| ▸ | THRA | P10827 | 3/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.32 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354279 | 0.89 | MEN1 (0.37) | PGRMEN1KMT2AALDH1A1AKR1C1 | |
| SCHEMBL5398376 | 0.70 | XIAP (0.44) | MEN1KMT2AALDH1A1AKR1C1THRB | |
| SCHEMBL5388975 | 0.69 | THRB (0.65) | MEN1KMT2AALDH1A1AKR1C1THRB | |
| SCHEMBL5381969 | 0.68 | THRB (0.59) | MEN1KMT2AALDH1A1AKR1C1THRB | |
| SCHEMBL5389009 | 0.68 | THRA (0.39) | PGRKMT2ATHRBTHRA | |
| SCHEMBL7207954 | 0.64 | PGR (0.48) | PGRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL24112733 | 0.61 | PGR (0.69) | PGRMEN1KMT2APOLBCDYL2 | |
| SCHEMBL3290496 | 0.61 | AKR1C1 (0.59) | MEN1KMT2AALDH1A1AKR1C1AKR1C3 | |
| SCHEMBL3290499 | 0.61 | AKR1C1 (0.59) | MEN1KMT2AALDH1A1AKR1C1AKR1C3 | |
| SCHEMBL13744294 | 0.60 | AKR1C2 (0.76) | MEN1KMT2AALDH1A1AKR1C1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199265-B2 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones | KARO BIO AB (SE) | 2007-04-03 | — | — | US | disclosed |
| US-20040097589-A1 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones | KARO BIO AB (SE) | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097589-A1 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones | TSHR, THRA, THRB | PGR 138/4885MEN1 386/4885KMT2A 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.