Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5378736 | 0.98 | KDM4E (0.48) | KDM4ENPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL10070110 | 0.85 | CES2 (0.46) | KDM4ENPC1RAB9ASMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL1652876 | 0.84 | CES2 (0.44) | KDM4ENPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL8266769 | 0.80 | TSHR (0.50) | NPC1RAB9ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL4696206 | 0.79 | TSHR (0.46) | NPC1RAB9ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL8299666 | 0.78 | NLRP3 (0.41) | KDM4ENPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL10855093 | 0.78 | TSHR (0.48) | KDM4ENPC1RAB9ASMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL3127844 | 0.78 | TSHR (0.48) | NPC1RAB9ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL10040529 | 0.78 | CES2 (0.46) | NPC1RAB9ATSHRCES2CES1 | |
| SCHEMBL10070511 | 0.78 | TSHR (0.47) | KDM4ERAB9ATSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024129395-A1 | BTK INHIBITORS | GWYNANT THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |
| CN-115197138-B | Preparation method of isoquinoline derivative | 广东工业大学 | 2023-12-15 | — | — | CN | disclosed |
| US-8212049-B2 | Electronically tuned ligands for asymmetric hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-03 | — | — | US | disclosed |
| US-8212049-B2 | Electronically tuned ligands for asymmetric hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-03 | — | — | US | disclosed |
| US-20110257393-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-20 | — | — | US | disclosed |
| US-20110257393-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-20 | — | — | US | disclosed |
| US-7994335-B2 | Electronically tuned ligands for asymmetric hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-09 | — | — | US | disclosed |
| US-7994335-B2 | Electronically tuned ligands for asymmetric hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-09 | — | — | US | disclosed |
| US-20100041898-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
| US-20100041898-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
| WO-2008067218-A1 | ELECTRONICALLY TUNED LIGANDS FOR ASYMMETRIC HYDROGENATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-06-05 | — | — | WO | disclosed |
| US-7256196-B1 | Purine cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2007-08-14 | — | — | US | disclosed |
| EP-1656360-A1 | THIAZOLINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-17 | — | — | EP | disclosed |
| WO-2004113309-A1 | THIAZOLINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041898-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BID, HDHD5, HRH4 | KDM4E 4189/4885NPC1 3908/4885RAB9A 2255/4885 |
| US-20110257393-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BID, HDHD5, HRH4 | KDM4E 4189/4885NPC1 3908/4885RAB9A 2255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.