SCHEMBL5397276

SCHEMBL5397276

NS(=O)(=O)c1ccc(CCN(CCC(=O)O)C(=O)c2ccccc2-c2ccccc2C(=O)NCCc2ccccc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA1 P00915 8/20 0.56
CA2 P00918 8/20 0.56
CA9 Q16790 4/20 0.56
CA12 O43570 4/20 0.55
CA4 P22748 3/20 0.55
CA5A P35218 1/20 0.54
CA7 P43166 1/20 0.54
CA5B Q9Y2D0 1/20 0.54
ALDH1A1 P00352 2/20 0.53
LMNA P02545 1/20 0.53
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
KMT2A Q03164 3/20 0.51
MEN1 O00255 2/20 0.51
RXFP1 Q9HBX9 1/20 0.51
GAA P10253 1/20 0.50
POLB P06746 1/20 0.49
TAAR1 Q96RJ0 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5401053 0.92 CA2 (0.55) CA1CA2CA9CA12CA4
SCHEMBL5399241 0.90 NPC1 (0.51) ALDH1A1LMNANPC1RAB9APOLB
SCHEMBL5394820 0.89 CA1 (0.51) CA1CA2CA9CA12CA4
SCHEMBL5398932 0.87 CA2 (0.49) CA1CA2CA12CA4ALDH1A1
SCHEMBL5398456 0.87 CA2 (0.54) CA1CA2CA9CA12CA4
SCHEMBL5400913 0.87 CA2 (0.53) CA1CA2CA9CA12CA4
SCHEMBL5403803 0.86 NPC1 (0.51) ALDH1A1NPC1RAB9AKMT2AMEN1
SCHEMBL5400679 0.86 CA2 (0.54) CA1CA2CA12CA4ALDH1A1
SCHEMBL5401176 0.86 CA1 (0.49) CA1CA2CA12CA4KMT2A
SCHEMBL5403109 0.86 CA2 (0.49) CA1CA2CA12CA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7285680-B2 β-alanine derivatives and the use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2007-10-23 US disclosed
US-20050256160-A1 Beta-alanine derivatives and the use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2005-11-17 US disclosed
EP-1533294-A1 BETA-ALANINE DERIVATIVE AND USE THEREOF ONO PHARMACEUTICAL CO., LTD. (JP) 2005-05-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050256160-A1 Beta-alanine derivatives and the use thereof TGFB1, PML, APOB CA1 722/4885CA2 1987/4885CA9 1086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.