Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.80 |
| ▸ | DNMT1 | P26358 | 5/20 | 0.68 |
| ▸ | AHCY | P23526 | 1/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
| ▸ | DNMT3B | Q9UBC3 | 5/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.56 |
| ▸ | PNMT | P11086 | 1/20 | 0.56 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5397399 | 1.00 | ADORA3 (0.80) | ADORA3DNMT1AHCYNT5EDNMT3B | |
| SCHEMBL5353522 | 0.89 | ADORA3 (1.00) | ADORA3DNMT1NT5EDNMT3BDOT1L | |
| SCHEMBL5354287 | 0.89 | ADORA3 (1.00) | ADORA3DNMT1NT5EDNMT3BDOT1L | |
| SCHEMBL5349929 | 0.86 | ADORA3 (1.00) | ADORA3DNMT1DNMT3BDOT1LPNMT | |
| SCHEMBL5349938 | 0.86 | ADORA3 (1.00) | ADORA3DNMT1DNMT3BDOT1LPNMT | |
| SCHEMBL2827171 | 0.85 | AHCY (0.79) | ADORA3DNMT1AHCYDNMT3BDOT1L | |
| SCHEMBL19433018 | 0.85 | AHCY (0.79) | ADORA3DNMT1AHCYDNMT3BDOT1L | |
| SCHEMBL17551956 | 0.85 | AHCY (0.79) | ADORA3DNMT1AHCYDNMT3BDOT1L | |
| SCHEMBL2827179 | 0.85 | AHCY (0.79) | ADORA3DNMT1AHCYDNMT3BDOT1L | |
| SCHEMBL5354088 | 0.85 | ADORA3 (1.00) | ADORA3DNMT1AHCYNT5EDNMT3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189706-B2 | C2,5′-disubstituted and N6,C2,5′-trisubstituted adenosine derivatives and pharmaceutical compositions containing them | UNIVERSITEIT LEIDEN (NL) | 2007-03-13 | — | — | US | disclosed |
| US-7084127-B2 | C2,5′-disubstituted and N6, C2,5′-trisubstituted adenosine derivatives and their different uses | UNIVERSITEIT LEIDEN (NL) | 2006-08-01 | — | — | US | disclosed |
| US-20050277615-A1 | Pharmaceutical compositions having anti-inflammatory activity | CAN-FITE BIOPHARMA LTD. (IL) | 2005-12-15 | — | — | US | disclosed |
| WO-2005111053-A2 | PHARMACEUTICAL COMPOSITIONS HAVING ANTI-INFLAMMATORY ACTIVITY | CAN-FITE BIOPHARMA LTD. (IL) | 2005-11-24 | — | — | WO | disclosed |
| US-20040132686-A1 | C2,5'- disubstituted and N6, c2,5'- trisubstituted adenosine derivatives and their different uses | UNIVERSITEIT LEIDEN (NL) | 2004-07-08 | — | — | US | disclosed |
| US-20040127452-A1 | C2,5'-disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and pharmaceutical compositions containing them | UNIVERSITEIT LEIDEN (NL) | 2004-07-01 | — | — | US | disclosed |
| EP-1368365-A2 | C2,5'-DISUBSTITUTED AND N6,C2,5'-TRISUBSTITUTED ADENOSINE DERIVATIVES AND THEIR DIFFERENT USES | Universiteit Leiden (NL) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070532-A2 | C2,5'-DISUBSTITUTED AND N6,C2,5'-TRISUBSTITUTED ADENOSINE DERIVATIVES AND THEIR DIFFERENT USES | UNIVERSITEIT LEIDEN (NL) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127452-A1 | C2,5'-disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and pharmaceutical compositions containing them | ADORA2A, ADORA3, ADORA1 | ADORA3 2/4885DNMT1 2984/4885AHCY 425/4885 |
| US-20050277615-A1 | Pharmaceutical compositions having anti-inflammatory activity | AHR, MSR1, ALOX15 | ADORA3 32/4885DNMT1 4737/4885AHCY 738/4885 |
| US-20040132686-A1 | C2,5'- disubstituted and N6, c2,5'- trisubstituted adenosine derivatives and their different uses | ADORA2A, ADORA3, ADORA1 | ADORA3 2/4885DNMT1 2526/4885AHCY 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.