Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fludrocortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | FNTA | P49354 | 2/20 | 0.75 |
| ▸ | FNTB | P49356 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | AR | P10275 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fludrocortisone Acetate SCHEMBL4737 | 1.00 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone Acetate SCHEMBL10871295 | 1.00 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone Acetate SCHEMBL20494161 | 0.97 | NR3C1 (0.93) | NR3C1HIF1APGRHRH1FNTA | |
| SCHEMBL11685662 | 0.91 | NR3C1 (0.84) | NR3C1HIF1APGRHRH1FNTA | |
| SCHEMBL11685669 | 0.91 | NR3C1 (0.84) | NR3C1HIF1APGRHRH1FNTA | |
| SCHEMBL11685664 | 0.91 | NR3C1 (0.84) | NR3C1HIF1APGRHRH1FNTA | |
| SCHEMBL29440662 | 0.89 | HIF1A (0.80) | NR3C1HIF1APGRHRH1FNTA | |
| SCHEMBL8735124 | 0.89 | NR3C1 (0.87) | NR3C1HIF1APGRHRH1FNTA | |
| SCHEMBL8735123 | 0.89 | NR3C1 (0.87) | NR3C1HIF1APGRHRH1FNTA | |
| SCHEMBL9277542 | 0.88 | HIF1A (0.79) | NR3C1HIF1APGRHRH1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414375-A1 | NOVEL AMIDE DERIVATIVES OF STEROIDALÝ3,2-C¨PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | AstraZeneca AB (SE) | 2012-02-08 | — | — | EP | disclosed |
| EP-2414377-A1 | NOVEL DERIVATIVES OF STEROIDALÝ3,2-C¨PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | AstraZeneca AB (SE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114476-A1 | NOVEL DERIVATIVES OF STEROIDAL[3,2-C]PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114471-A1 | NOVEL AMIDE DERIVATIVES OF STEROIDAL[3,2-C]PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |