Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fludrocortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.93 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.93 |
| ▸ | PGR | P06401 | 3/20 | 0.93 |
| ▸ | HRH1 | P35367 | 1/20 | 0.93 |
| ▸ | FNTA | P49354 | 2/20 | 0.71 |
| ▸ | FNTB | P49356 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.66 |
| ▸ | AR | P10275 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fludrocortisone Acetate SCHEMBL4737 | 0.97 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone Acetate SCHEMBL10871295 | 0.97 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone Acetate SCHEMBL539744 | 0.97 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone SCHEMBL21297043 | 0.92 | NR3C1 (0.96) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone SCHEMBL23975175 | 0.92 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone SCHEMBL4545 | 0.92 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone SCHEMBL10598529 | 0.92 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone SCHEMBL13026141 | 0.92 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone SCHEMBL14373312 | 0.92 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA | |
| Fludrocortisone SCHEMBL4323075 | 0.92 | NR3C1 (1.00) | NR3C1HIF1APGRHRH1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200199538-A1 | DERIVATION OF LIVER ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS | AGENCY FOR SCIENCE TECH AND RESEARCH ASTARSTAR (SG) | 2020-06-25 | — | — | US | claimed |
| CN-110582564-A | derivation of liver organoids from human pluripotent stem cells | 新加坡科技研究局 | 2019-12-17 | — | — | CN | claimed |
| US-20200199538-A1 | DERIVATION OF LIVER ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS | AGENCY FOR SCIENCE TECH AND RESEARCH ASTARSTAR (SG) | 2020-06-25 | — | — | US | disclosed |
| CN-110582564-A | derivation of liver organoids from human pluripotent stem cells | 新加坡科技研究局 | 2019-12-17 | — | — | CN | disclosed |
| US-20180258400-A1 | DERIVATION OF LIVER ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2018-09-13 | — | — | US | disclosed |