Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | RHOC | P08134 | 2/20 | 0.46 |
| ▸ | RHOA | P61586 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5399828 | 0.86 | GAA (0.63) | ALDH1A1GAATDP1GLAHSD17B10 | |
| SCHEMBL5633304 | 0.84 | ALDH1A1 (0.53) | ALDH1A1GAATDP1GLAHSD17B10 | |
| SCHEMBL4462380 | 0.81 | ALDH1A1 (0.50) | ALDH1A1GAATDP1GLAHSD17B10 | |
| SCHEMBL22622323 | 0.79 | GLA (0.70) | ALDH1A1GAATDP1GLAHSD17B10 | |
| SCHEMBL30946669 | 0.78 | RHOA (0.62) | GAATDP1GLAHSD17B10RHOC | |
| SCHEMBL12061833 | 0.77 | ALDH1A1 (0.52) | ALDH1A1GAATDP1MEN1KMT2A | |
| SCHEMBL5633990 | 0.76 | GAA (0.62) | ALDH1A1GAAHSD17B10KMT2APOLB | |
| SCHEMBL3284280 | 0.75 | SMN1; SMN2 (0.68) | ALDH1A1GAATDP1GLAHSD17B10 | |
| SCHEMBL16695142 | 0.75 | SMN1; SMN2 (0.68) | ALDH1A1GAATDP1GLAHSD17B10 | |
| SCHEMBL5634807 | 0.75 | ALDH1A1 (0.44) | ALDH1A1GAATDP1GLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007518742-A | — | — | 2007-07-12 | — | — | JP | claimed |
| EP-1718633-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-11-08 | — | — | EP | claimed |
| WO-2005070919-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-08-04 | — | — | WO | claimed |
| EP-1718633-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005070919-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-08-04 | — | — | WO | disclosed |