Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695142 | 1.00 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTGLAHSD17B10ACHE | |
| SCHEMBL22622323 | 0.92 | GLA (0.70) | SMN1; SMN2HTTGLAHSD17B10PDK2 | |
| SCHEMBL4724682 | 0.91 | SMN1; SMN2 (0.66) | SMN1; SMN2HTTGLAHSD17B10ACHE | |
| SCHEMBL3319140 | 0.91 | HSD17B10 (0.74) | SMN1; SMN2HTTGLAHSD17B10HPGD | |
| SCHEMBL3319143 | 0.91 | HSD17B10 (0.74) | SMN1; SMN2HTTGLAHSD17B10HPGD | |
| SCHEMBL9029952 | 0.90 | SMN1; SMN2 (0.82) | SMN1; SMN2HTTACHEMGLLHSD11B1 | |
| SCHEMBL16695294 | 0.87 | ACHE (0.60) | SMN1; SMN2ACHEEPHX2PDK2MGLL | |
| SCHEMBL27812707 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTGLAHSD17B10ACHE | |
| SCHEMBL22622475 | 0.86 | GLA (0.72) | SMN1; SMN2HTTGLAHSD17B10MEN1 | |
| SCHEMBL1719734 | 0.85 | MGLL (0.68) | ACHEEPHX2MGLLHSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714019-B2 | Indole, azaindole and related heterocyclic pyrrolidine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-05-11 | — | — | US | disclosed |
| US-20090186933-A1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2009-07-23 | — | — | US | disclosed |
| US-7531552-B2 | Indole, azaindole and related heterocyclic pyrrolidine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-05-12 | — | — | US | disclosed |
| EP-1474135-B9 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2008-08-06 | — | — | EP | disclosed |
| US-20080096912-A1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2008-04-24 | — | — | US | disclosed |
| EP-1474135-B1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2007-11-21 | — | — | EP | disclosed |
| US-20060287531-A1 | Indole, azaindole and related heterocyclic pyrrolidine derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2006-12-21 | — | — | US | disclosed |
| EP-1474135-A4 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2006-01-18 | — | — | EP | disclosed |
| EP-1474135-A1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 2004-11-10 | — | — | EP | disclosed |
| US-20030236277-A1 | Indole, azaindole and related heterocyclic pyrrolidine derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2003-12-25 | — | — | US | disclosed |
| WO-2003068221-A1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096912-A1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | IDO1, IDO2, INMT | SMN1; SMN2 4835/4885HTT 1086/4885GLA 4283/4885 |
| US-20090186933-A1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES | IDO1, IDO2, INMT | SMN1; SMN2 4835/4885HTT 1086/4885GLA 4283/4885 |
| US-20060287531-A1 | Indole, azaindole and related heterocyclic pyrrolidine derivatives | IDO1, IDO2, INMT | SMN1; SMN2 4835/4885HTT 1086/4885GLA 4283/4885 |
| US-20030236277-A1 | Indole, azaindole and related heterocyclic pyrrolidine derivatives | IDO1, IDO2, INMT | SMN1; SMN2 4835/4885HTT 1086/4885GLA 4283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.