Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deanol SCHEMBL4708447 | 0.88 | CYP1A2 (0.32) | SLC22A6TDP1 | |
| SCHEMBL20898290 | 0.82 | — | — | |
| SCHEMBL549356 | 0.82 | — | — | |
| SCHEMBL19809590 | 0.79 | — | — | |
| SCHEMBL1860971 | 0.79 | — | — | |
| SCHEMBL9392015 | 0.79 | — | — | |
| SCHEMBL8008574 | 0.79 | — | — | |
| SCHEMBL4299562 | 0.79 | — | — | |
| SCHEMBL1138591 | 0.79 | — | — | |
| SCHEMBL1138621 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007149343-A2 | PROTEASES FOR TREATMENT OF VENOMOUS BITES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-12-27 | — | — | WO | disclosed |
| US-5790627-A | Method and apparatus for observing a specimen using an X-ray microscope | RESEARCH DEVELOPMENT CORP. (JP) | 1998-08-04 | — | — | US | disclosed |
| US-5733721-A | ANALYZING CELLS FROM BLADDERS BY APPLYING TO A SLIDE WITH EDTA, RADIATION AND DETECTION OF IMAGES | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 1998-03-31 | — | — | US | disclosed |