Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.54 |
| ▸ | GCGR | P47871 | 13/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | FRK | P42685 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377577 | 0.91 | CDC7 (0.49) | MAPK13MAPK12PRKD3CSNK1A1CSNK1D | |
| SCHEMBL5380873 | 0.85 | MAPK14 (0.49) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL7395689 | 0.85 | MAPK14 (0.48) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5384093 | 0.85 | GCGR (0.56) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5381545 | 0.84 | CDC7 (0.59) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5383543 | 0.81 | PKN1 (0.53) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5380413 | 0.80 | NPC1 (0.56) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5381418 | 0.78 | CYP19A1 (0.54) | GSK3BCDC7 | |
| SCHEMBL5376057 | 0.78 | KMT2A (0.54) | CDC7 | |
| SCHEMBL5381446 | 0.77 | GSK3B (0.47) | MAPK14GCGRMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |