Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377577 | 0.91 | CDC7 (0.49) | MAPK13MAPK12GSK3BCSNK1DALDH1A1 | |
| SCHEMBL5399995 | 0.85 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL5384093 | 0.85 | GCGR (0.56) | MAPK14MAPK13RAF1MAPK12MAPK11 | |
| SCHEMBL7395689 | 0.85 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL5381545 | 0.84 | CDC7 (0.59) | MAPK14MAPK13RAF1BRAFMAPK12 | |
| SCHEMBL5383543 | 0.81 | PKN1 (0.53) | MAPK14MAPK13RAF1MAPK12MAPK11 | |
| SCHEMBL5380413 | 0.80 | NPC1 (0.56) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL5381418 | 0.78 | CYP19A1 (0.54) | GSK3BALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL5376057 | 0.78 | KMT2A (0.54) | BRAFALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL5380875 | 0.77 | GSK3B (0.75) | MAPK14MAPK13RAF1BRAFMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |