Hydrochloric Acid

Hydrochloric Acid

SCHEMBL540140

[Cl-].[Cl-].[Hf+2]C1c2ccccc2-c2ccccc21

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 3/20 0.40
CHRM2 known ✓ P08172 1/20 0.40
CHRM1 known ✓ P11229 1/20 0.40
SLC6A2 known ✓ P23975 1/20 0.40
SLC6A3 known ✓ Q01959 1/20 0.40
GPR3 P46089 2/20 0.44
HTR2A P28223 2/20 0.44
HTR1A P08908 1/20 0.40
ADRA2A P08913 1/20 0.40
DRD1 P21728 1/20 0.40
SLC6A4 P31645 1/20 0.40
ADRA1A P35348 1/20 0.40
OPRM1 P35372 1/20 0.40
DRD3 P35462 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
CYP19A1 P11511 1/20 0.39
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC8 Q9BY41 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL27522793 0.94 GPR3 (0.44) GPR3HTR2AACHECHRM2HTR1A
Hydrochloric Acid SCHEMBL9579939 0.76 MYC (0.38) GPR3HTR2AACHEKMT2AMEN1
Hydrochloric Acid SCHEMBL4093570 0.76 GPR3 (0.35) GPR3HTR2APOLB
Hydrochloric Acid SCHEMBL3385863 0.73 GPR3 (0.46) GPR3HTR2AACHECHRM2HTR1A
SCHEMBL6936104 0.73 GPR3 (0.46) GPR3HTR2AACHECHRM2HTR1A
SCHEMBL524603 0.71 GPR3 (0.50) GPR3HTR2AACHECHRM2HTR1A
SCHEMBL29950614 0.71 GPR3 (0.50) GPR3HTR2AACHECHRM2HTR1A
Hydrochloric Acid SCHEMBL6812758 0.71 GPR3 (0.44) GPR3HTR2AACHECHRM2HTR1A
Hydrochloric Acid SCHEMBL1985361 0.71 GPR3 (0.44) GPR3HTR2AACHECHRM2HTR1A
SCHEMBL6814556 0.71 HTR2A (0.50) GPR3HTR2AACHECHRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392743-A2 CATALYST COMPOSITION, METHOD OF POLYMERIZATION AND POLYMER THEREFROM Univation Technologies LLC (US) 2004-03-03 EP claimed
US-20040039138-A1 Catalyst preparation method WENZEL TIMOTHY T (US) 2004-02-26 US claimed
US-20030207762-A9 CATALYST PREPARATION METHOD UNIVATION TECHNOLOGIES, LLC 2003-11-06 US claimed
EP-1358216-A2 START-UP PROCEDURE FOR MULTIPLE CATALYST POLYMERIZATION SYSTEMS Univation Technologies LLC (US) 2003-11-05 EP claimed
US-6620894-B2 Calibration; using coordination catalyst UNIVATION TECHNOLOGIES, LLC 2003-09-16 US claimed
US-20020132937-A1 Start-up procedure for multiple catalyst polymerization systems UNIVATION TECHNOLOGIES, LLC 2002-09-19 US claimed
US-20020119890-A1 Catalyst preparation method WENZEL TIMOTHY T (US) 2002-08-29 US claimed
US-20020103310-A1 Catalyst composition, method of polymerization and polymer therefrom UNIVATION TECHNOLOGIES, LLC 2002-08-01 US claimed
WO-2002050127-A2 START-UP PROCEDURE FOR MULTIPLE CATALYST POLYMERIZATION SYSTEMS UNIVATION TECHNOLOGIES, LLC (US) 2002-06-27 WO claimed
WO-2002046250-A2 CATALYST COMPOSITION, METHOD OF POLYMERIZATION AND POLYMER THEREFROM UNIVATION TECHNOLOGIES, LLC (US) 2002-06-13 WO claimed
EP-4384556-A1 PROCESS FOR PRODUCING POLYOLEFIN GRANULAR RESIN WITH INCREASED SETTLED BULK DENSITY W. R. Grace & Co.-Conn (US) 2024-06-19 EP disclosed
CN-118202023-A Polypropylene viscosity modifier and lubricating oil thereof 埃克森美孚化学专利公司 2024-06-14 CN disclosed
CN-117736358-A Metallocene polyethylene for sintering and preparation method and application thereof 上海化工研究院有限公司 2024-03-22 CN disclosed
WO-2023177433-A1 PROCESS FOR PRODUCING HEAT TREATED SUPPORTED ALUMINOXANES IN AN ALIPHATIC SOLVENT USING SOLID ALUMINOXANES W.R. GRACE & CO.-CONN. (US) 2023-09-21 WO disclosed
WO-2023178116-A1 SILICA-SUPPORTED POLYOLEFIN CATALYST SYSTEM W. R. GRACE & CO.-CONN (US) 2023-09-21 WO disclosed
EP-0668295-A1 Spray dried, filled metallocene catalyst composition for use in polyolefin manufacture UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1995-08-23 EP disclosed
US-5434115-A Process for producing olefin polymer TOSOH CORPORATION (JP) 1995-07-18 US disclosed
US-5317036-A Continuous catalytic vapor phase polymerization of olefins UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-05-31 US disclosed
EP-0593083-A1 Gas phase polymerization reaction utilizing soluble unsupported catalysts UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-04-20 EP disclosed
US-4892851-A Process and catalyst for producing syndiotactic polyolefins FINA TECHNOLOGY, INC. (US) 1990-01-09 US disclosed