Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL524602 | 0.84 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL30103334 | 0.84 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL2877998 | 0.81 | PNMT (0.61) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL27361865 | 0.79 | PGR (0.42) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL22263591 | 0.79 | PNMT (0.57) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL27885618 | 0.77 | PNMT (0.57) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL3385861 | 0.77 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL3381704 | 0.77 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL395592 | 0.77 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL7760609 | 0.77 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539477-A | Preparation method of ethylene propylene diene monomer | 浙江大学衢州研究院 | 2022-05-27 | — | — | CN | claimed |
| CN-114539478-A | Preparation method of comb-shaped polyolefin thermoplastic elastomer based on feeding strategy regulation and control | 浙江大学衢州研究院 | 2022-05-27 | — | — | CN | claimed |
| EP-1392743-A2 | CATALYST COMPOSITION, METHOD OF POLYMERIZATION AND POLYMER THEREFROM | Univation Technologies LLC (US) | 2004-03-03 | — | — | EP | claimed |
| US-20040039138-A1 | Catalyst preparation method | WENZEL TIMOTHY T (US) | 2004-02-26 | — | — | US | claimed |
| US-20030207762-A9 | CATALYST PREPARATION METHOD | UNIVATION TECHNOLOGIES, LLC | 2003-11-06 | — | — | US | claimed |
| EP-1358216-A2 | START-UP PROCEDURE FOR MULTIPLE CATALYST POLYMERIZATION SYSTEMS | Univation Technologies LLC (US) | 2003-11-05 | — | — | EP | claimed |
| US-6620894-B2 | Calibration; using coordination catalyst | UNIVATION TECHNOLOGIES, LLC | 2003-09-16 | — | — | US | claimed |
| US-20020132937-A1 | Start-up procedure for multiple catalyst polymerization systems | UNIVATION TECHNOLOGIES, LLC | 2002-09-19 | — | — | US | claimed |
| US-20020119890-A1 | Catalyst preparation method | WENZEL TIMOTHY T (US) | 2002-08-29 | — | — | US | claimed |
| US-20020103310-A1 | Catalyst composition, method of polymerization and polymer therefrom | UNIVATION TECHNOLOGIES, LLC | 2002-08-01 | — | — | US | claimed |
| WO-2002050127-A2 | START-UP PROCEDURE FOR MULTIPLE CATALYST POLYMERIZATION SYSTEMS | UNIVATION TECHNOLOGIES, LLC (US) | 2002-06-27 | — | — | WO | claimed |
| WO-2002046250-A2 | CATALYST COMPOSITION, METHOD OF POLYMERIZATION AND POLYMER THEREFROM | UNIVATION TECHNOLOGIES, LLC (US) | 2002-06-13 | — | — | WO | claimed |
| EP-4384556-A1 | PROCESS FOR PRODUCING POLYOLEFIN GRANULAR RESIN WITH INCREASED SETTLED BULK DENSITY | W. R. Grace & Co.-Conn (US) | 2024-06-19 | — | — | EP | disclosed |
| CN-118055955-A | Process for producing polyolefin granular resins with increased settled bulk density | 格雷斯公司 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023177433-A1 | PROCESS FOR PRODUCING HEAT TREATED SUPPORTED ALUMINOXANES IN AN ALIPHATIC SOLVENT USING SOLID ALUMINOXANES | W.R. GRACE & CO.-CONN. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023178116-A1 | SILICA-SUPPORTED POLYOLEFIN CATALYST SYSTEM | W. R. GRACE & CO.-CONN (US) | 2023-09-21 | — | — | WO | disclosed |
| US-5434115-A | Process for producing olefin polymer | TOSOH CORPORATION (JP) | 1995-07-18 | — | — | US | disclosed |
| US-5317036-A | Continuous catalytic vapor phase polymerization of olefins | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1994-05-31 | — | — | US | disclosed |
| EP-0593083-A1 | Gas phase polymerization reaction utilizing soluble unsupported catalysts | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-4892851-A | Process and catalyst for producing syndiotactic polyolefins | FINA TECHNOLOGY, INC. (US) | 1990-01-09 | — | — | US | disclosed |