Sugi Predict

Sugi Predict / Compounds / SCHEMBL540147

SCHEMBL540147

SCHEMBL540147

O=C1c2ccccc2C(=O)N1Cc1ccc(Br)cc1[N+](=O)[O-]

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 2/20 0.60
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ RXFP1 Q9HBX9 1/20 0.50
▸ TYR P14679 1/20 0.50
▸ GRM5 P41594 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.45
▸ HTT P42858 1/20 0.45
▸ PRMT5 O14744 1/20 0.44
▸ WDR77 Q9BQA1 1/20 0.44
▸ CA12 O43570 2/20 0.43
▸ CA2 P00918 2/20 0.43
▸ CA9 Q16790 2/20 0.43
▸ LMNA P02545 1/20 0.43
▸ AGTR1 P30556 1/20 0.43
▸ S100A4 P26447 1/20 0.43
▸ TRPV1 Q8NER1 1/20 0.43
▸ CTDSP1 Q9GZU7 1/20 0.42
▸ GSK3B P49841 2/20 0.42
▸ GABRP O00591 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11259879 0.83 GRM5 (0.60) ACHEMEN1KMT2ARXFP1TYR
SCHEMBL540166 0.83 GRM5 (0.52) ACHEMEN1KMT2ARXFP1TYR
SCHEMBL9196427 0.83 MEN1 (0.50) ACHEMEN1KMT2ARXFP1TYR
SCHEMBL2806608 0.82 MEN1 (0.49) ACHEMEN1KMT2ARXFP1TYR
SCHEMBL4047966 0.82 TYR (0.67) ACHEMEN1KMT2ARXFP1TYR
SCHEMBL30216837 0.79 GRM5 (0.53) ACHEMEN1KMT2ARXFP1TYR
SCHEMBL28962650 0.79 GRM5 (0.53) ACHEMEN1KMT2ARXFP1TYR
SCHEMBL10920293 0.78 KMT2A (0.48) MEN1KMT2ARXFP1TYRGRM5
SCHEMBL4477320 0.77 GRM5 (0.51) RXFP1TYRGRM5ALDH1A1PRMT5
SCHEMBL14723531 0.77 CHRM5 (0.53) MEN1KMT2ATYRGRM5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624044-B2 SMARCA degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2026-05-12 — — US disclosed
US-20230072658-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-03-09 — — US disclosed
WO-2020251971-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2020-12-17 — — WO disclosed
EP-3095780-A1 PESTICIDAL ARYLPYRROLIDINES Bayer Intellectual Property GmbH (DE) 2016-11-23 — — EP disclosed
US-9271499-B2 Pesticidal arylpyrrolidines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-03-01 — — US disclosed
US-9266830-B2 Pesticidal arylpyrrolidines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-02-23 — — US disclosed
US-20150152086-A1 Insecticidal Aryl Pyrrolidines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-06-04 — — US disclosed
US-8980937-B2 Insecticidal aryl pyrrolidines BAYER CROPSCIENCE AG (DE) 2015-03-17 — — US disclosed
US-20150073139-A1 Pesticidal Arylpyrrolidines BAYER CROPSCIENCE AG (DE) 2015-03-12 — — US disclosed
US-20150011553-A1 Pesticidal Arylpyrrolidines BAYER CROPSCIENCE AG (DE) 2015-01-08 — — US disclosed
US-20120232278-A1 Insecticidal Aryl Pyrrolidines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2012-09-13 — — US disclosed
EP-2463265-A2 Process for the preparation of insecticidal aryl pyrrolidines Bayer CropScience AG (DE) 2012-06-13 — — EP disclosed
US-8188122-B2 Insecticidal aryl pyrrolidines BAYER CROPSCIENCE AG (DE) 2012-05-29 — — US disclosed
EP-2148853-B1 INSECTICIDAL ARYL PYRROLIDINES BAYER CROPSCIENCE AG (DE) 2012-02-08 — — EP disclosed
EP-2349994-A1 PESTICIDAL (HETERO) ARYLPYRROLIDINES BAYER CROPSCIENCE AG (DE) 2011-08-03 — — EP disclosed
US-20110082175-A1 INSECTICIDAL ARYL PYRROLIDINES BAYER CROPSCIENCE AG (DE) 2011-04-07 — — US disclosed
US-20100216792-A1 Pesticidal arylpyrrolidines BAYER CROPSCIENCE AG (DE) 2010-08-26 — — US disclosed
WO-2010043315-A1 PESTICIDAL (HETERO) ARYLPYRROLIDINES BAYER CROPSCIENCE AG (DE) 2010-04-22 — — WO disclosed
EP-2148853-A1 INSECTICIDAL ARYL PYRROLIDINES BAYER CROPSCIENCE AG (DE) 2010-02-03 — — EP disclosed
WO-2008128711-A1 INSECTICIDAL ARYL PYRROLIDINES BAYER CROPSCIENCE AG (DE) 2008-10-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150011553-A1 Pesticidal Arylpyrrolidines DDT, AADAC, AHR ACHE 4/4885MEN1 3599/4885KMT2A 1019/4885
US-20120232278-A1 Insecticidal Aryl Pyrrolidines DDT, ITPR3, CYP51A1 ACHE 53/4885MEN1 4820/4885KMT2A 1815/4885
US-20150152086-A1 Insecticidal Aryl Pyrrolidines DDT, ITPR3, CYP51A1 ACHE 53/4885MEN1 4820/4885KMT2A 1815/4885
US-20110082175-A1 INSECTICIDAL ARYL PYRROLIDINES DDT, ITPR3, CYP51A1 ACHE 53/4885MEN1 4820/4885KMT2A 1815/4885
US-20100216792-A1 Pesticidal arylpyrrolidines DDT, AADAC, AHR ACHE 4/4885MEN1 3599/4885KMT2A 1019/4885
US-20150073139-A1 Pesticidal Arylpyrrolidines DDT, ACHE, QDPR ACHE 2/4885MEN1 3163/4885KMT2A 749/4885
US-12624044-B2 SMARCA degraders and uses thereof SMARCA1, SMARCC1, SMARCA2 ACHE 3904/4885MEN1 1936/4885KMT2A 212/4885
US-20230072658-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCB1, SMARCE1 ACHE 3092/4885MEN1 1348/4885KMT2A 380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.