SCHEMBL5401604

SCHEMBL5401604

NC(=O)CC(=O)NCCC(F)(F)C(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ECE1 P42892 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4057292 0.83 CFTR (0.35) ECE1ALDH1A1POLBSMN1; SMN2
SCHEMBL4423626 0.82 ECE1 (0.36) ECE1ALDH1A1POLBSMN1; SMN2
SCHEMBL3911271 0.79 PGK1 (0.31) CA2
SCHEMBL5399207 0.77 ST14 (0.30)
SCHEMBL5405580 0.76 ALDH1A1 (0.39) ECE1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL5396143 0.76 ALDH1A1 (0.31) ALDH1A1
SCHEMBL3907990 0.74 ALDH1A1 (0.34) CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL25076167 0.72 KDM4E (0.46) ALDH1A1POLBSMN1; SMN2
SCHEMBL5396140 0.72 ALDH1A1 (0.35) CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL27784613 0.72 ECE1 (0.37) ECE1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007505063-A 2007-03-08 JP claimed
EP-1711470-A1 MALONAMIDE DERIVATIVES BLOCKING THE ACTIVTIY OF GAMMA-SECRETASE F. HOFFMANN-LA ROCHE AG (CH) 2006-10-18 EP claimed
WO-2005023772-A1 MALONAMIDE DERIVATIVES BLOCKING THE ACTIVITY OF GAMA-SECRETASE F. HOFFMANN-LA ROCHE AG (CH) 2005-03-17 WO claimed
EP-1711470-A1 MALONAMIDE DERIVATIVES BLOCKING THE ACTIVTIY OF GAMMA-SECRETASE F. HOFFMANN-LA ROCHE AG (CH) 2006-10-18 EP disclosed
WO-2005023772-A1 MALONAMIDE DERIVATIVES BLOCKING THE ACTIVITY OF GAMA-SECRETASE F. HOFFMANN-LA ROCHE AG (CH) 2005-03-17 WO disclosed