Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CA3 | P07451 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | CASP2 | P42575 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057292 | 0.88 | CFTR (0.35) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL26066649 | 0.82 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL29700581 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL3950393 | 0.78 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL18896201 | 0.78 | MEN1 (0.64) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL5401604 | 0.76 | ECE1 (0.31) | ALDH1A1SMN1; SMN2POLBCA2ECE1 | |
| SCHEMBL3917161 | 0.74 | LMNA (0.37) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL5620319 | 0.74 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL5399207 | 0.73 | ST14 (0.30) | — | |
| SCHEMBL10323553 | 0.72 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007505063-A | — | — | 2007-03-08 | — | — | JP | claimed |
| EP-1711470-A1 | MALONAMIDE DERIVATIVES BLOCKING THE ACTIVTIY OF GAMMA-SECRETASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-18 | — | — | EP | claimed |
| WO-2005023772-A1 | MALONAMIDE DERIVATIVES BLOCKING THE ACTIVITY OF GAMA-SECRETASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-17 | — | — | WO | claimed |