Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.41 |
| ▸ | CCR1 | P32246 | 10/20 | 0.39 |
| ▸ | CCR2 | P41597 | 10/20 | 0.39 |
| ▸ | CCR4 | P51679 | 8/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14610530 | 0.72 | CCR1 (0.49) | CYP19A1CCR1CCR2CCR4CYP3A4 | |
| SCHEMBL12468796 | 0.70 | CYP19A1 (0.50) | CYP19A1CCR1CCR2CCR4DPP4 | |
| SCHEMBL5468353 | 0.69 | DPP4 (0.50) | CYP19A1CCR1CCR2CCR4DPP4 | |
| SCHEMBL1398129 | 0.68 | DPP4 (0.36) | DPP4CYP3A4 | |
| SCHEMBL3153071 | 0.67 | CYP19A1 (0.67) | CYP19A1CYP3A4 | |
| SCHEMBL29820189 | 0.67 | CYP19A1 (0.67) | CYP19A1CCR1CCR2CCR4NOTUM | |
| SCHEMBL5301838 | 0.67 | CCR1 (0.54) | CYP19A1CCR1CCR2CCR4CYP3A4 | |
| SCHEMBL27864568 | 0.66 | CYP11B1 (0.50) | CYP19A1CCR1CCR2CCR4NOTUM | |
| SCHEMBL12468753 | 0.66 | CYP19A1 (0.55) | CYP19A1CCR1CCR2DPP4 | |
| SCHEMBL7468845 | 0.64 | CYP19A1 (0.56) | CYP19A1CCR1CCR2CCR4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |