Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 11/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405518 | 0.91 | MET (0.67) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL5406649 | 0.90 | MET (0.83) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL5406604 | 0.90 | MET (0.66) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL5405465 | 0.90 | MET (0.82) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL14595081 | 0.86 | MET (0.63) | METKDRFGFR1PDGFRBAURKB | |
| SCHEMBL5413896 | 0.85 | MET (0.75) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL5409007 | 0.83 | AURKB (0.49) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL5406612 | 0.81 | MET (0.83) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL5409933 | 0.81 | MET (0.72) | METALKKDRFGFR1PDGFRB | |
| SCHEMBL5413334 | 0.81 | MET (0.82) | METALKKDRFGFR1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | SUGEN, INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | DMPK, MAP3K20, PHKG1 | MET 2590/4885ALK 612/4885KDR 1657/4885 |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | CHEK2, CHEK1, ATM | MET 2434/4885ALK 1165/4885KDR 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.