Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | FLT1 | P17948 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.54 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403331 | 0.91 | MET (0.67) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5406612 | 0.90 | MET (0.83) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5406604 | 0.90 | MET (0.66) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5409933 | 0.90 | MET (0.72) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5405465 | 0.90 | MET (0.82) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5401554 | 0.89 | KDR (0.72) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5406770 | 0.88 | MET (0.68) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5413323 | 0.87 | MET (0.73) | METALKKDRFLT1PDGFRB | |
| SCHEMBL14595091 | 0.86 | KDR (0.58) | METALKKDRFLT1PDGFRB | |
| SCHEMBL5413896 | 0.85 | MET (0.75) | METALKKDRPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | SUGEN, INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | DMPK, MAP3K20, PHKG1 | MET 2590/4885ALK 612/4885KDR 1657/4885 |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | CHEK2, CHEK1, ATM | MET 2434/4885ALK 1165/4885KDR 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.