Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 16/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5414827 | 0.99 | ACHE (0.54) | ACHE | |
| SCHEMBL5273960 | 0.99 | ACHE (0.57) | ACHEELANE | |
| Hydrochloric Acid SCHEMBL5406241 | 0.84 | ACHE (0.38) | ACHE | |
| SCHEMBL5277342 | 0.82 | ACHE (0.38) | ACHE | |
| Hydrochloric Acid SCHEMBL5409420 | 0.82 | ACHE (0.56) | ACHE | |
| Hydrochloric Acid SCHEMBL5414145 | 0.81 | ACHE (0.54) | ACHE | |
| SCHEMBL6260768 | 0.77 | ELANE (0.43) | ELANE | |
| SCHEMBL6260759 | 0.77 | ELANE (0.43) | ELANE | |
| Hydrochloric Acid SCHEMBL5414135 | 0.77 | ACHE (0.33) | ACHE | |
| SCHEMBL5272686 | 0.74 | ACHE (1.00) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223865-B2 | Chromogenic compounds, and use thereof as enzyme substrates | BIOMERIEUX (FR) | 2007-05-29 | — | — | US | disclosed |
| US-20060035306-A1 | Enzyme substrates, culture media containing same and use thereof in order to detect aminopeptidase activity and/or differentiate gram-positive bacteria from gram-negative bacteria | BIOMERIEUX (FR) | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035306-A1 | Enzyme substrates, culture media containing same and use thereof in order to detect aminopeptidase activity and/or differentiate gram-positive bacteria from gram-negative bacteria | ANPEP, RNPEP, DNPEP | ACHE 393/4885ELANE 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.