Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.52 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.32 |
| ▸ | DPYD | Q12882 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653178 | 0.71 | AXL (0.41) | DYRK1A | |
| SCHEMBL5497510 | 0.71 | ATM (0.47) | — | |
| SCHEMBL2300723 | 0.70 | IMPDH2 (0.52) | IMPDH2IMPDH1DYRK1ALRRK2CCNT1 | |
| SCHEMBL186741 | 0.68 | IMPDH2 (1.00) | IMPDH2IMPDH1DYRK1ALRRK2 | |
| SCHEMBL29820843 | 0.68 | IMPDH2 (1.00) | IMPDH2IMPDH1DYRK1ALRRK2 | |
| SCHEMBL2307532 | 0.68 | IMPDH2 (0.58) | IMPDH2IMPDH1DYRK1ALRRK2CCNT1 | |
| Hydrochloric Acid SCHEMBL7697252 | 0.67 | IMPDH2 (0.96) | IMPDH2IMPDH1DYRK1ALRRK2CCNT1 | |
| SCHEMBL28328494 | 0.67 | IMPDH2 (0.96) | IMPDH2IMPDH1DYRK1ALRRK2CCNT1 | |
| Hydrochloric Acid SCHEMBL7431978 | 0.67 | IMPDH2 (0.96) | IMPDH2IMPDH1DYRK1ALRRK2CCNT1 | |
| SCHEMBL27631244 | 0.66 | HTR2C (0.44) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437793-A | Crystalline (3-cyano-1H-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate | MERCK PATENT GMBH (DE) | 2009-05-20 | — | — | CN | claimed |
| US-7312342-B2 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-12-25 | — | — | US | disclosed |
| CN-1319532-C | Use of N- (indolylcarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2007-06-06 | — | — | CN | disclosed |
| CN-1213029-C | Process for the preparation of (3-cyano-1H-indol-7-yl) (4-(4-fluorophenethyl)piperazin-1-yl)-methanone and salts thereof | MERCH PATENT GMBH (DE) | 2005-08-03 | — | — | CN | disclosed |
| CN-1589147-A | Use of N-(indolecarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-03-02 | — | — | CN | disclosed |
| CN-1487923-A | Process for the preparation of (3-cyano-1H-indol-7-yl) (4- (4-fluorophenethyl) piperazin-1-yl) -methanone and salts thereof | Ĭ��ר���ɷ�����˾ | 2004-04-07 | — | — | CN | disclosed |
| CN-1487923-A | Process for the preparation of (3-cyano-1H-indol-7-yl) (4- (4-fluorophenethyl) piperazin-1-yl) -methanone and salts thereof | Ĭ��ר���ɷ�����˾ | 2004-04-07 | — | — | CN | disclosed |
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | TPH1, TPH2, IDO1 | IMPDH2 483/4885IMPDH1 333/4885DYRK1A 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.