Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12628038 | 0.92 | POLB (0.52) | POLBROCK2ROCK1ERN1CCR2 | |
| SCHEMBL3536081 | 0.88 | POLB (0.52) | POLBROCK2ROCK1CCR2SLC6A2 | |
| SCHEMBL5409001 | 0.87 | ROCK2 (0.47) | POLBROCK2ROCK1CCR2SLC6A2 | |
| SCHEMBL13438658 | 0.85 | ULK1 (0.49) | POLBROCK2ROCK1ERN1CCR2 | |
| SCHEMBL5405984 | 0.85 | ROCK2 (0.53) | POLBROCK2ROCK1CCR2SLC6A2 | |
| SCHEMBL11934772 | 0.85 | ULK1 (0.49) | POLBROCK2ROCK1ERN1CCR2 | |
| SCHEMBL5418817 | 0.82 | ROCK2 (0.48) | POLBROCK2ROCK1CCR2TRPM5 | |
| SCHEMBL4165570 | 0.79 | ERN1 (0.42) | ROCK2ROCK1ERN1 | |
| SCHEMBL3532732 | 0.79 | IDO1 (0.54) | POLBROCK2ROCK1CCR2TDO2 | |
| SCHEMBL1716563 | 0.79 | ROCK2 (0.62) | ROCK2ROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | POLB 3765/4885ROCK2 2/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.