Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | CCR3 | P51677 | 10/20 | 0.54 |
| ▸ | HRH1 | P35367 | 7/20 | 0.54 |
| ▸ | SPR | P35270 | 1/20 | 0.53 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 2/20 | 0.48 |
| ▸ | ACACA | Q13085 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5398564 | 0.89 | CCR3 (0.57) | L3MBTL3L3MBTL1CCR3HRH1MBTD1 | |
| SCHEMBL5419347 | 0.79 | STS (0.49) | CCR3HRH1KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL5411458 | 0.77 | HRH1 (0.84) | CCR3HRH1KCNH2KMT2A | |
| SCHEMBL18840737 | 0.77 | CCR3 (0.80) | L3MBTL3L3MBTL1CCR3HRH1CHRM2 | |
| SCHEMBL5405007 | 0.77 | KDM2B (0.43) | CCR3HRH1KCNH2CHRM2KMT2A | |
| SCHEMBL1806612 | 0.76 | CA12 (0.62) | SPRKMT2APOLB | |
| SCHEMBL27669216 | 0.73 | L3MBTL3 (0.94) | L3MBTL3L3MBTL1MBTD1KDM4EKMT2A | |
| SCHEMBL10293557 | 0.73 | L3MBTL3 (1.00) | L3MBTL3L3MBTL1MBTD1KDM4EKMT2A | |
| SCHEMBL9447404 | 0.71 | ACHE (0.51) | SPR | |
| SCHEMBL5457332 | 0.71 | LRRK2 (0.79) | L3MBTL3L3MBTL1MBTD1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179297-A1 | Chemical compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2007-08-02 | — | — | US | disclosed |
| US-7238811-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-03 | — | — | US | disclosed |
| US-7179922-B2 | 4-Phenyloxypiperidionopiperidine compounds as antiinflammatory agents; autoimmune diseases; rheumatic diseases; cardiovascular disorders | ASTRAZENECA AB (SE) | 2007-02-20 | — | — | US | disclosed |
| US-20050171092-A1 | Chemical compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2005-08-04 | — | — | US | disclosed |
| EP-1274701-B1 | [1,4']-BIPIPERIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2005-06-29 | — | — | EP | disclosed |
| US-6903115-B2 | Bipiperidine compounds | ASTRAZENECA AB (SE) | 2005-06-07 | — | — | US | disclosed |
| EP-1493743-A1 | Substituted bipiperidine intermediates and derivatives thereof | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| US-20040014783-A1 | Chemical compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2004-01-22 | — | — | US | disclosed |
| US-20040006080-A1 | Chemical compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2004-01-08 | — | — | US | disclosed |
| US-6525070-B2 | For therapy of chemokine (such as CCR3) or H1 mediated disease state | ASTRAZENECA AB (SE) | 2003-02-25 | — | — | US | disclosed |
| US-20020077337-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2002-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077337-A1 | Chemical compounds | CCR3, CCR1, CCR4 | L3MBTL3 3352/4885L3MBTL1 3977/4885CCR3 1/4885 |
| US-20050171092-A1 | Chemical compounds | CCR3, CCR1, CCR4 | L3MBTL3 3148/4885L3MBTL1 4086/4885CCR3 1/4885 |
| US-20040006080-A1 | Chemical compounds | CCR3, CCR1, CCR4 | L3MBTL3 3352/4885L3MBTL1 3977/4885CCR3 1/4885 |
| US-20040014783-A1 | Chemical compounds | CCR3, CCR1, CCR4 | L3MBTL3 3352/4885L3MBTL1 3977/4885CCR3 1/4885 |
| US-20070179297-A1 | Chemical compounds | CCR3, CCR1, CCR4 | L3MBTL3 3148/4885L3MBTL1 4086/4885CCR3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.