Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5277348 | 0.99 | IDO1 (0.45) | IDO1ACHECITLPAR1MAPT | |
| Hydrochloric Acid SCHEMBL5414138 | 0.84 | IDO1 (0.41) | IDO1MAPTKDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5404002 | 0.82 | HTT (0.47) | ACHEMAPTALDH1A1POLBHTT | |
| Hydrochloric Acid SCHEMBL5404008 | 0.79 | ACHE (0.62) | IDO1ACHECITTAAR1 | |
| Hydrochloric Acid SCHEMBL5414835 | 0.78 | ACHE (0.60) | IDO1ACHECITTAAR1 | |
| SCHEMBL5273957 | 0.78 | ACHE (0.63) | IDO1ACHECITTAAR1 | |
| Hydrochloric Acid SCHEMBL5406241 | 0.73 | ACHE (0.38) | ACHEALDH1A1 | |
| SCHEMBL7738209 | 0.72 | IDO1 (0.67) | IDO1LPAR1KDM4EALDH1A1TAAR1 | |
| SCHEMBL6265104 | 0.72 | ACHE (0.58) | IDO1ACHEALDH1A1 | |
| SCHEMBL5277342 | 0.71 | ACHE (0.38) | ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223865-B2 | Chromogenic compounds, and use thereof as enzyme substrates | BIOMERIEUX (FR) | 2007-05-29 | — | — | US | disclosed |
| US-20060035306-A1 | Enzyme substrates, culture media containing same and use thereof in order to detect aminopeptidase activity and/or differentiate gram-positive bacteria from gram-negative bacteria | BIOMERIEUX (FR) | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035306-A1 | Enzyme substrates, culture media containing same and use thereof in order to detect aminopeptidase activity and/or differentiate gram-positive bacteria from gram-negative bacteria | ANPEP, RNPEP, DNPEP | ACHE 393/4885IDO1 221/4885CIT 2391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.