Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.34 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL540137 | 0.92 | MEN1 (0.38) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL9922054 | 0.91 | MAPT (0.41) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL539977 | 0.89 | MAPT (0.39) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL539626 | 0.89 | SIRT6 (0.45) | SMN1; SMN2ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL27929451 | 0.85 | MAPT (0.36) | ALDH1A1MAPTLMNAHTTL3MBTL1 | |
| SCHEMBL539910 | 0.83 | SIRT6 (0.38) | ALDH1A1MAPTLMNAHTTL3MBTL1 | |
| SCHEMBL539569 | 0.80 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL540319 | 0.80 | MEN1 (0.43) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL540579 | 0.80 | AR (0.37) | SMN1; SMN2MAPTHTTAR | |
| SCHEMBL8931745 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103483235-B | The aryl pyrrolidines of desinsection | BAYER LANDWIRTSCHAFTLICHE KULTURPFLANZEN SCIENCE AG (DE) | 2015-09-09 | — | — | CN | disclosed |
| US-20150152086-A1 | Insecticidal Aryl Pyrrolidines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| US-8980937-B2 | Insecticidal aryl pyrrolidines | BAYER CROPSCIENCE AG (DE) | 2015-03-17 | — | — | US | disclosed |
| CN-101663261-B | Insecticidal arylpyrrolidines | BAYER CROPSCIENCE AG | 2014-07-16 | — | — | CN | disclosed |
| US-20120232278-A1 | Insecticidal Aryl Pyrrolidines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-09-13 | — | — | US | disclosed |
| EP-2463265-A2 | Process for the preparation of insecticidal aryl pyrrolidines | Bayer CropScience AG (DE) | 2012-06-13 | — | — | EP | disclosed |
| US-8188122-B2 | Insecticidal aryl pyrrolidines | BAYER CROPSCIENCE AG (DE) | 2012-05-29 | — | — | US | disclosed |
| EP-2148853-B1 | INSECTICIDAL ARYL PYRROLIDINES | BAYER CROPSCIENCE AG (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20110082175-A1 | INSECTICIDAL ARYL PYRROLIDINES | BAYER CROPSCIENCE AG (DE) | 2011-04-07 | — | — | US | disclosed |
| EP-2148853-A1 | INSECTICIDAL ARYL PYRROLIDINES | BAYER CROPSCIENCE AG (DE) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008128711-A1 | INSECTICIDAL ARYL PYRROLIDINES | BAYER CROPSCIENCE AG (DE) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232278-A1 | Insecticidal Aryl Pyrrolidines | DDT, ITPR3, CYP51A1 | SMN1; SMN2 3047/4885ALDH1A1 261/4885MAPT 4582/4885 |
| US-20150152086-A1 | Insecticidal Aryl Pyrrolidines | DDT, ITPR3, CYP51A1 | SMN1; SMN2 3047/4885ALDH1A1 261/4885MAPT 4582/4885 |
| US-20110082175-A1 | INSECTICIDAL ARYL PYRROLIDINES | DDT, ITPR3, CYP51A1 | SMN1; SMN2 3047/4885ALDH1A1 261/4885MAPT 4582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.