Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28950924 | 0.88 | KDM4E (0.52) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5407133 | 0.85 | KDM4E (0.44) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL976779 | 0.84 | GABRP (0.41) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL27855771 | 0.82 | KDM4E (0.44) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10912988 | 0.81 | HSD17B10 (0.43) | KDM4EHSD17B10TP53KMT2AALDH1A1 | |
| SCHEMBL2382402 | 0.80 | ALDH1A1 (0.41) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL27554808 | 0.80 | HAAO (0.41) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2930434 | 0.79 | KDM4E (0.50) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30374425 | 0.78 | KDM4E (0.48) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1457096 | 0.78 | KDM4E (0.48) | KDM4EGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | disclosed |