Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.54 |
| ▸ | CCR2 | P41597 | 2/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.46 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.46 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.46 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5412921 | 0.94 | IKBKB (0.59) | IKBKBROCK1ROCK2CCR2CHRM4 | |
| SCHEMBL5418070 | 0.89 | ROCK1 (0.64) | IKBKBROCK1ROCK2CCR2CHRM4 | |
| SCHEMBL5419161 | 0.89 | ROCK2 (0.61) | IKBKBROCK1ROCK2CCR2CHRM4 | |
| SCHEMBL5416024 | 0.89 | ROCK2 (0.61) | IKBKBROCK1ROCK2CCR2CHRM4 | |
| SCHEMBL5410417 | 0.87 | ROCK2 (0.60) | IKBKBROCK1ROCK2CCR2CHRM4 | |
| SCHEMBL5409613 | 0.87 | ROCK2 (0.60) | IKBKBROCK1ROCK2CCR2CHRM4 | |
| SCHEMBL5423957 | 0.86 | PRKCZ (0.63) | IKBKBROCK1ROCK2CCR2PRKCZ | |
| SCHEMBL26132172 | 0.85 | ROCK2 (0.64) | IKBKBROCK1ROCK2CCR2CHRM4 | |
| SCHEMBL20321367 | 0.83 | IKBKB (0.59) | IKBKBROCK1ROCK2CCR2PRKCZ | |
| SCHEMBL29595853 | 0.83 | IKBKB (0.59) | IKBKBROCK1ROCK2CCR2PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | IKBKB 633/4885ROCK1 1/4885ROCK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.