Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5407661 | 1.00 | HTT (0.41) | HTTTSHRALDH1A1LMNAFGFR4 | |
| Oxalic Acid SCHEMBL11437762 | 0.92 | HTT (0.39) | HTTTSHRALDH1A1LMNAFGFR4 | |
| SCHEMBL361077 | 0.85 | ALDH1A1 (0.38) | ALDH1A1 | |
| Water SCHEMBL5407251 | 0.82 | ALDH1A1 (0.35) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL142823 | 0.82 | ALDH1A1 (0.35) | ALDH1A1 | |
| Bromide SCHEMBL4276596 | 0.82 | ALDH1A1 (0.35) | ALDH1A1 | |
| Sulfuric Acid SCHEMBL23277225 | 0.81 | CA5A (0.32) | HTT | |
| Sulfuric Acid SCHEMBL23277224 | 0.81 | CA5A (0.32) | HTT | |
| Bicarbonate SCHEMBL8039493 | 0.79 | HTT (0.38) | HTTTSHRALDH1A1LMNAMAPT | |
| SCHEMBL7047715 | 0.79 | KMT2A (0.41) | HTTTSHRALDH1A1LMNAABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7239018-B2 | Composition for forming a porous film prepared by hydrolysis and condensation of an alkoxysilane using a trialkylmethylammonium hydroxide catalyst | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2007-07-03 | — | — | US | disclosed |
| US-20040180554-A1 | Composition for forming porous film and method for forming the same, porous film and method for forming the same, interlevel insulator film, and semiconductor device | SHIN-ETSU CHEMICAL CO., LTD. | 2004-09-16 | — | — | US | disclosed |