Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14447537 | 0.88 | KCNH2 (0.48) | NPY5RNPC1RAB9A | |
| SCHEMBL12209610 | 0.81 | ALDH1A1 (0.57) | NPY5RKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL14447538 | 0.81 | NPC1 (0.51) | NPY5RKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL14447476 | 0.81 | NPC1 (0.50) | KDM4EMAPTLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL16609461 | 0.77 | NPY5R (0.44) | NPY5RCACNA1GCACNA1HKDM4EMAPT | |
| SCHEMBL16599521 | 0.77 | NPY5R (0.44) | NPY5RCACNA1GCACNA1HKDM4EMAPT | |
| SCHEMBL3728479 | 0.75 | PARP1 (0.43) | KDM4EMAPTNPC1RAB9AGFER | |
| SCHEMBL2595517 | 0.75 | TLR9 (0.48) | NPC1RAB9APARP1 | |
| SCHEMBL7217488 | 0.75 | PARP1 (0.46) | KDM4EMAPTNPC1RAB9AGFER | |
| SCHEMBL14447528 | 0.75 | KDM4E (0.57) | KDM4EMAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244847-B2 | Benzimidazole compounds | ISIS PHARMACEUTICALS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244847-B2 | Benzimidazole compounds | ISIS PHARMACEUTICALS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244847-B2 | Benzimidazole compounds | ISIS PHARMACEUTICALS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| WO-2004047769-A2 | BENZIMIDAZOLES AND ANALOGS THEREOF AS ANTIBACTERIALS | ISIS PHARMACEUTICALS, INC. (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20030187258-A1 | Novel benzimidazole compounds | US GOVERNMENT - SECRETARY FOR THE ARMY | 2003-10-02 | — | — | US | disclosed |
| WO-2003066622-A1 | NOVEL BENZIMIDAZOLE COMPOUNDS | ISIS, PHARMACEUTICALS (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187258-A1 | Novel benzimidazole compounds | BRD4, BRI3BP, BRD3 | NPY5R 4755/4885CACNA1G 4642/4885CACNA1H 4717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.