Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.62 |
| ▸ | CCR2 | P41597 | 5/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | MARK3 | P27448 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5404960 | 0.86 | ROCK2 (0.67) | ROCK2ROCK1CCR2DRD4CDC7 | |
| SCHEMBL4313225 | 0.80 | MAPK14 (0.61) | DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6232404 | 0.79 | KMT2A (0.71) | DRD4 | |
| SCHEMBL24172739 | 0.78 | CYP3A4 (0.58) | ROCK2ROCK1CYP3A4JAK2GSK3B | |
| SCHEMBL15515501 | 0.78 | CYP3A4 (0.58) | ROCK2ROCK1CYP3A4JAK2GSK3B | |
| SCHEMBL5639760 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1CCR2DRD4 | |
| SCHEMBL5407412 | 0.77 | MAPK14 (0.70) | ROCK2ROCK1CCR2MAPK1PRKAA1 | |
| SCHEMBL23647459 | 0.77 | ROCK2 (0.56) | ROCK2ROCK1CCR2CDC7JAK2 | |
| SCHEMBL224917 | 0.76 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL2798618 | 0.76 | CDC7 (0.59) | ROCK2ROCK1CYP3A4CDC7CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | ROCK2 2/4885ROCK1 1/4885CCR2 2824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.