Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924721 | 0.82 | SMN1; SMN2 (0.73) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL14681415 | 0.81 | LMNA (0.64) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL12281819 | 0.80 | SMN1; SMN2 (0.72) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL12280663 | 0.79 | HPGD (0.71) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL11489588 | 0.79 | HIF1A (0.65) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL21637701 | 0.78 | KDM4E (0.70) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL9972174 | 0.78 | ALDH1A1 (1.00) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL20131163 | 0.76 | HDAC6 (0.68) | LMNASMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL1368915 | 0.73 | ALDH1A1 (0.71) | LMNARAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1368527 | 0.73 | HIF1A (1.00) | LMNASMN1; SMN2HPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413696-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | Mount Sinai School Of Medicine Of New York University (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010114636-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY (US) | 2010-10-07 | — | — | WO | claimed |
| EP-2413696-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | Mount Sinai School Of Medicine Of New York University (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114636-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY (US) | 2010-10-07 | — | — | WO | disclosed |