Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992628 | 0.80 | ALDH1A1 (0.67) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL21637701 | 0.78 | KDM4E (0.70) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL1368527 | 0.78 | HIF1A (1.00) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL3924721 | 0.78 | SMN1; SMN2 (0.73) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL541201 | 0.78 | LMNA (0.76) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL12281819 | 0.77 | SMN1; SMN2 (0.72) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL1368915 | 0.75 | ALDH1A1 (0.71) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL8190292 | 0.74 | ALDH1A1 (0.65) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL13155648 | 0.74 | ALDH1A1 (0.65) | ALDH1A1HPGDSMN1; SMN2MAPTHIF1A | |
| SCHEMBL8198190 | 0.73 | ALDH1A1 (0.63) | ALDH1A1HPGDSMN1; SMN2MAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202861-B2 | Drugs for various disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |
| US-8202861-B2 | Drugs for various disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |