Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465653 | 1.00 | ALDH1A1 (0.38) | ALDH1A1TSHRCES1KCNN4PTPN1 | |
| SCHEMBL5161276 | 1.00 | ALDH1A1 (0.38) | ALDH1A1TSHRCES1KCNN4PTPN1 | |
| SCHEMBL13785277 | 0.81 | ALDH1A1 (0.38) | ALDH1A1TSHRCES1KCNN4PTPN1 | |
| SCHEMBL13785278 | 0.81 | ALDH1A1 (0.38) | ALDH1A1TSHRCES1KCNN4PTPN1 | |
| SCHEMBL7356506 | 0.80 | ALDH1A1 (0.39) | ALDH1A1TSHRKCNN4PTPN1NR1H2 | |
| SCHEMBL1401085 | 0.79 | ALDH1A1 (0.35) | ALDH1A1TSHRKCNN4PTPN1NR1H2 | |
| SCHEMBL4080546 | 0.76 | KCNN4 (0.44) | ALDH1A1TSHRCES1KCNN4PTPN1 | |
| SCHEMBL17091567 | 0.75 | KCNN4 (0.34) | ALDH1A1TSHRCES1KCNN4PTPN1 | |
| SCHEMBL7873896 | 0.71 | ALDH1A1 (0.46) | ALDH1A1TSHRCES1KCNN4MAPK1 | |
| SCHEMBL1229735 | 0.71 | CES1 (0.42) | ALDH1A1TSHRCES1KCNN4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469887-B1 | Acetamide derivatives | ZENECA LTD (GB) | 1994-12-14 | — | — | EP | claimed |
| US-5270342-A | Acetamide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-14 | — | — | US | claimed |
| EP-1663255-B1 | WITHANAMIDE AND WITHANOLIDE COMPOSITIONS AND METHOD OF USE THEREOF | UNIV MICHIGAN STATE (US) | 2014-11-12 | — | — | EP | disclosed |
| US-7282593-B2 | Withanamide and withanolide compositions and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-10-16 | — | — | US | disclosed |
| EP-1702910-A1 | OCTAHYDRONAPHTHALENE DERIVATIVE AND MEDICINE | Nippon Shinyaku Co., Ltd. (JP) | 2006-09-20 | — | — | EP | disclosed |
| US-20050059727-A1 | Withanamide and withanolide compositions and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2005-03-17 | — | — | US | disclosed |
| EP-0648130-B1 | RADIOIODINATED BENZOVESAMICOL ANALOGS FOR CHOLINERGIC NERVE MAPPING | UNIV MICHIGAN (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5430060-A | Aldose reductase inhibitor | ZENECA LIMITED (GB) | 1995-07-04 | — | — | US | disclosed |
| US-5270342-A | Acetamide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-14 | — | — | US | disclosed |
| US-5077035-A | Scintigraphic imaging of brain; Alzheimer*s diagnosis | THE UNIVERSITY OF MICHIGAN (US) | 1991-12-31 | — | — | US | disclosed |
| US-4772727-A | Method of producing enantiomerically pure R-(+)-alpha-lipoic acid and S-(-)a | DEGUSSA (DE) | 1988-09-20 | — | — | US | disclosed |
| EP-0261336-A2 | Process for the preparation of pure enantiomers of R-(+)-alpha-lipoic acid and S-(-)-alpha-lipoic acid (thioctic acid), and nonene or mesyl derivatives as intermediates therefor | ASTA Medica Aktiengesellschaft (DE) | 1988-03-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059727-A1 | Withanamide and withanolide compositions and method of use thereof | ACHE, CYP51A1, HASPIN | ALDH1A1 1849/4885TSHR 3754/4885CES1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.