Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1043227 | 0.85 | CA2 (0.44) | PTGS1PDE4ASLC22A6KDM4ECYP3A4 | |
| SCHEMBL126970 | 0.84 | — | — | |
| SCHEMBL1904 | 0.84 | — | — | |
| SCHEMBL2058760 | 0.84 | CA5A (0.46) | PTGS1PDE4ASLC22A6KDM4ECYP3A4 | |
| Sulfuric Acid SCHEMBL6727151 | 0.81 | CA5A (0.46) | PTGS1PDE4AKDM4ECYP3A4CA5A | |
| SCHEMBL4460080 | 0.81 | — | — | |
| Methyl Alcohol SCHEMBL23421569 | 0.81 | — | — | |
| SCHEMBL20533648 | 0.81 | — | — | |
| SCHEMBL20533683 | 0.81 | — | — | |
| SCHEMBL20583855 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238489-B2 | Identification of sortase gene | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-07-03 | — | — | US | disclosed |
| US-7101692-B2 | Identification of sortase gene | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-09-05 | — | — | US | disclosed |
| US-20060073530-A1 | Methods and compositions involving sortase B | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-04-06 | — | — | US | disclosed |
| EP-1416955-A4 | IDENTIFICATION OF SORTASE GENE | UNIV CALIFORNIA (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20050069984-A1 | Identification of sortase gene | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-03-31 | — | — | US | disclosed |
| EP-1233780-A4 | IDENTIFICATION OF SORTASE GENE | UNIV CALIFORNIA (US) | 2004-09-22 | — | — | EP | disclosed |
| US-6773706-B2 | Identification of sortase gene | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-08-10 | — | — | US | disclosed |
| EP-1416955-A2 | IDENTIFICATION OF SORTASE GENE | The Regents of the University of California (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003020885-A9 | IDENTIFICATION OF SORTASE GENE | UNIV CALIFORNIA (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20030153020-A1 | Identification of sortase gene | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-08-14 | — | — | US | disclosed |
| WO-2003020885-A2 | IDENTIFICATION OF SORTASE GENE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-03-13 | — | — | WO | disclosed |
| US-20030022178-A1 | Identification of sortase gene | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-01-30 | — | — | US | disclosed |
| EP-1233780-A1 | IDENTIFICATION OF SORTASE GENE | The Regents of the University of California (US) | 2002-08-28 | — | — | EP | disclosed |
| WO-2000062804-A2 | IDENTIFICATION OF SORTASE GENE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-10-26 | — | — | WO | disclosed |
| WO-1999009145-A1 | IDENTIFICATION OF SORTASE GENE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-02-25 | — | — | WO | disclosed |