Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.57 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429364 | 0.78 | PTGS1 (0.40) | PTGDR2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL4158192 | 0.78 | CYP3A4 (0.48) | ALDH1A1TP53CYP1A2CYP3A4ALOX15 | |
| SCHEMBL3787150 | 0.77 | KIF11 (0.61) | ALDH1A1MAPK1MAPTL3MBTL1KIF11 | |
| SCHEMBL7054031 | 0.77 | PTGDR2 (0.48) | PTGDR2NOS3NOS1NOS2LMNA | |
| SCHEMBL3785538 | 0.76 | GCK (0.38) | PTGDR2ALDH1A1TP53CYP3A4MAPK1 | |
| SCHEMBL18586254 | 0.76 | KIF11 (0.44) | ALDH1A1MAPK1KIF11PKM | |
| SCHEMBL5431464 | 0.75 | PTGDR2 (0.46) | PTGDR2KIF11PTGS2 | |
| SCHEMBL12493701 | 0.74 | PTGDR2 (0.50) | PTGDR2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL3792211 | 0.74 | KIF11 (0.52) | PTGDR2ALDH1A1MAPK1MAPTL3MBTL1 | |
| SCHEMBL16193476 | 0.74 | L3MBTL1 (0.59) | PTGDR2LMNANPSR1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249686-A1 | Modulators of Crth-2 Receptor Activity for the Treatment of Prostaglandin D2 Mediated Diseases | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249686-A1 | Modulators of Crth-2 Receptor Activity for the Treatment of Prostaglandin D2 Mediated Diseases | PTGDR2, PTGDR, PTGER2 | PTGDR2 1/4885CCR2 462/4885NOS3 3410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.