Toluene

Toluene

SCHEMBL5420163

Cc1ccc(S(=O)(=O)N[C@H]2CCCC[C@@H]2N)cc1.Cc1ccccc1.[Ru]

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.55
TSHR P16473 2/20 0.55
CYP3A4 P08684 1/20 0.55
NPSR1 Q6W5P4 1/20 0.52
MCOLN2 Q8IZK6 3/20 0.51
MCOLN1 Q9GZU1 3/20 0.51
MCOLN3 Q8TDD5 2/20 0.51
MMP2 P08253 2/20 0.49
MMP9 P14780 2/20 0.49
MMP13 P45452 2/20 0.49
MMP14 P50281 2/20 0.49
PSEN1 P49768 2/20 0.48
PSEN2 P49810 2/20 0.48
APH1B Q8WW43 2/20 0.48
NCSTN Q92542 2/20 0.48
APH1A Q96BI3 2/20 0.48
PSENEN Q9NZ42 2/20 0.48
MMP1 P03956 1/20 0.48
MMP3 P08254 1/20 0.48
THRB P10828 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL5423398 1.00 ALDH1A1 (0.55) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
Benzene SCHEMBL5180862 0.97 ALDH1A1 (0.57) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
Benzene SCHEMBL5181252 0.97 ALDH1A1 (0.57) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
P-Xylene SCHEMBL5422459 0.94 ALDH1A1 (0.60) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
P-Xylene SCHEMBL5421280 0.94 ALDH1A1 (0.60) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
O-Xylene SCHEMBL5422893 0.93 ALDH1A1 (0.54) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
O-Xylene SCHEMBL5411640 0.93 ALDH1A1 (0.54) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
SCHEMBL6816353 0.93 ALDH1A1 (0.62) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
SCHEMBL419813 0.93 ALDH1A1 (0.62) ALDH1A1TSHRCYP3A4NPSR1MCOLN2
SCHEMBL987578 0.93 ALDH1A1 (0.62) ALDH1A1TSHRCYP3A4NPSR1MCOLN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7268250-B2 Process for producing optically active compound KANTO KAGAKU KABUSHIKI KAISHA (JP) 2007-09-11 US disclosed
US-20040176616-A1 Process for producing optically active compound KANTO KAGAKU KABUSHIKI KAISHA 2004-09-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040176616-A1 Process for producing optically active compound OSTC, NPEPPS, PPOX ALDH1A1 3566/4885TSHR 3616/4885CYP3A4 77/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.