Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.41 |
| ▸ | ROS1 | P08922 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.38 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5419348 | 0.79 | BRD4 (0.43) | ALKROS1EGFRLRRK2 | |
| SCHEMBL5410531 | 0.76 | LRRK2 (0.44) | EGFRLRRK2BCDIN3DNUDT1 | |
| SCHEMBL5416094 | 0.74 | NUDT1 (0.45) | ALKROS1EGFRLRRK2NUDT1 | |
| SCHEMBL5413361 | 0.74 | GLO1 (0.53) | EGFRLRRK2NUDT1 | |
| SCHEMBL5417363 | 0.73 | LRRK2 (0.46) | ALKLRRK2NUDT1 | |
| SCHEMBL5405496 | 0.73 | ALK (0.42) | ALKROS1LRRK2 | |
| SCHEMBL5408668 | 0.72 | LRRK2 (0.55) | LRRK2 | |
| SCHEMBL5405462 | 0.72 | STK17A (0.51) | LRRK2NUDT1 | |
| SCHEMBL5416108 | 0.70 | LRRK2 (0.48) | EGFRLRRK2NUDT1 | |
| SCHEMBL5413700 | 0.67 | HDAC3 (0.43) | ALKROS1EGFRIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166599-B2 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20050090486-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-04-28 | — | — | US | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | ALK 3651/4885ROS1 2088/4885EGFR 3316/4885 |
| US-20050090486-A1 | Trisubstituted pyrimidines | APP, BACE1, PSEN1 | ALK 2986/4885ROS1 2422/4885EGFR 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.