Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | PLA2G10 | O15496 | 7/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5208338 | 0.89 | ALDH1A1 (1.00) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL30194196 | 0.89 | ALDH1A1 (1.00) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL3957422 | 0.84 | ALDH1A1 (0.79) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL9260948 | 0.84 | ALDH1A1 (0.79) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL9149430 | 0.84 | ALDH1A1 (0.79) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL3578110 | 0.84 | ALDH1A1 (0.72) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL5434782 | 0.83 | ALDH1A1 (0.77) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| Dimethylamine SCHEMBL4930574 | 0.83 | ALDH1A1 (0.87) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL5247396 | 0.83 | ALDH1A1 (0.76) | ALDH1A1TSHRPLA2G10DAOMCL1 | |
| SCHEMBL28414221 | 0.81 | ALDH1A1 (0.73) | ALDH1A1TSHRPLA2G10DAOMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| CN-1882537-A | Substituted indolecarboxylic acid derivatives and their use as PAI-1 inhibitors | WYETH CORP (US) | 2006-12-20 | — | — | CN | disclosed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | disclosed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | IDO2, IDO1, INMT | ALDH1A1 414/4885TSHR 1990/4885PLA2G10 4131/4885 |
| US-20050113438-A1 | Substituted indoles | IDO2, IDO1, INMT | ALDH1A1 414/4885TSHR 1990/4885PLA2G10 4131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.