SCHEMBL5422396

SCHEMBL5422396

Cc1nc2c3c(c(C(=O)N4CC(O)C4)cn2c1C)CCC(c1ccccc1)O3

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ATP4A P20648 1/20 0.42
ATP4B P51164 1/20 0.42
CYP3A4 P08684 2/20 0.38
CYP2C9 P11712 2/20 0.38
SPR P35270 5/20 0.35
SLC8A1 P32418 3/20 0.34
RIPK1 Q13546 4/20 0.34
SCD5 Q86SK9 1/20 0.33
LMNA P02545 1/20 0.32
HPGD P15428 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
F11 P03951 1/20 0.32
HCRTR1 O43613 2/20 0.31
HCRTR2 O43614 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5417817 0.88 ATP4A (0.46) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL5989112 0.88 ATP4A (0.46) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL5414016 0.87 ATP4A (0.41) ATP4AATP4BCYP3A4CYP2C9SPR
SCHEMBL5571082 0.86 ATP4A (0.45) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL5425463 0.86 ATP4A (0.45) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL6028182 0.86 ATP4A (0.45) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL5570682 0.85 ATP4A (0.44) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL5567363 0.85 ATP4A (0.44) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL5566450 0.85 ATP4A (0.44) ATP4AATP4BCYP3A4CYP2C9SLC8A1
SCHEMBL5566826 0.85 ATP4A (0.43) ATP4AATP4BCYP3A4CYP2C9SLC8A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070191334-A1 Tricyclic imidazopyridines ALTANA PHARMA AG (DE) 2007-08-16 US disclosed
EP-1735318-A2 7H-8,9-DIHYDRO-PYRANO(2,3-C)IMIDAZO(1,2A)PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS Altana Pharma AG (DE) 2006-12-27 EP disclosed
WO-2005090358-A2 7H-8,9-DIHYDRO-PYRANO (2,3-C) IMIDAZO (1,2A) PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS ALTANA PHARMA AG (DE) 2005-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191334-A1 Tricyclic imidazopyridines GIPR, SLC10A2, MLNR ATP4A 131/4885ATP4B 510/4885CYP3A4 34/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.