Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429847 | 0.90 | LIPE (0.43) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5428771 | 0.89 | NR3C1 (0.39) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5425021 | 0.89 | NR3C1 (0.45) | NR3C1KMT2ACYP3A4CYP2D6TSHR | |
| SCHEMBL5422204 | 0.88 | CCR1 (0.39) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5427290 | 0.87 | LMNA (0.50) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5422001 | 0.86 | NR3C1 (0.43) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5429568 | 0.86 | NR3C1 (0.43) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5427073 | 0.85 | MCOLN3 (0.48) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5431821 | 0.85 | LIPE (0.44) | NR3C1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL5430005 | 0.85 | MEN1 (0.40) | NR3C1MEN1KMT2ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | ONO PHARMACEUTICAL CO., LTD. | 2007-11-29 | — | — | US | disclosed |
| EP-1683797-A1 | HETEROCYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | NR3C2, CBR1, CBR3 | NR3C1 7/4885MEN1 995/4885KMT2A 2691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.