Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.45 |
| ▸ | CDK2 | P24941 | 6/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5427237 | 0.87 | SMARCA2 (0.53) | CDK1CDK2PRMT5TRPV3ALOX5AP | |
| SCHEMBL5430325 | 0.86 | CDK1 (0.45) | CDK1CDK2PRMT5TRPV3ALOX5AP | |
| SCHEMBL5427559 | 0.84 | CDK1 (0.44) | CDK1CDK2PRMT5TRPV3ALOX5AP | |
| SCHEMBL5718732 | 0.83 | CDK1 (0.42) | CDK1CDK2PRMT5TRPV3ALOX5AP | |
| SCHEMBL5422694 | 0.82 | PRMT5 (0.42) | PRMT5TRPV3ALOX5APFEN1SMARCA2 | |
| SCHEMBL5424542 | 0.82 | CDK1 (0.48) | CDK1CDK2MAP3K12 | |
| SCHEMBL5425664 | 0.82 | SMARCA2 (0.44) | PRMT5TRPV3ALOX5APFEN1SMARCA2 | |
| Hydrochloric Acid SCHEMBL5432610 | 0.81 | CDK1 (0.47) | CDK1CDK2MAP3K12 | |
| Hydrochloric Acid SCHEMBL5435520 | 0.79 | CDK1 (0.42) | CDK1CDK2MAP3K12 | |
| SCHEMBL5432419 | 0.79 | IKBKB (0.44) | PRMT5TRPV3ALOX5APFEN1SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | ASTELLAS PHARMA INC. (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1736472-A1 | 2-AMINOPYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | NFKBIA, IKBKG, NFKB2 | CDK1 477/4885CDK2 26/4885PRMT5 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.