Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5422694 | 0.93 | PRMT5 (0.42) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5427341 | 0.91 | SMARCA2 (0.40) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5432419 | 0.90 | IKBKB (0.44) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5427237 | 0.90 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5429334 | 0.90 | USP30 (0.41) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5426125 | 0.89 | TRPV3 (0.45) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5427548 | 0.88 | PRMT5 (0.41) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5428318 | 0.88 | ALOX5AP (0.41) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5424220 | 0.88 | PRMT5 (0.51) | PRMT5USP30ALOX5APFEN1HPGDS | |
| SCHEMBL5424194 | 0.87 | CCNT1 (0.45) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | ASTELLAS PHARMA INC. (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1736472-A1 | 2-AMINOPYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | NFKBIA, IKBKG, NFKB2 | SMARCA2 3310/4885SMARCA4 3985/4885PBRM1 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.